This Project Grant award, totaling $770,558, was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The award will fund a research project titled "NEUROIMAGE-GENOMIC FINGERPRINTS FOR SUBTYPING AND PREDICTION OF ALZHEIMER'S DISEASE AND RELATED DEMENTIA" at Wake Forest University Health Sciences over a period of 5 years, from July 1, 2025 to March 31, 2030. The project aims to establish connections between Alzheimer's disease-related genomic...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $245,434 to Wake Forest University Health Sciences to examine the associations between early and later-life stress on later-life cognition and plasma biomarkers of Alzheimer's disease and related dementias (ADRD). The project aims to cross-sectionally analyze the relationship between life course stress and cognition or ADRD biomarkers, including amyloid-beta, tau proteins, and...
This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) program, provides $614,424 to the University of Washington to research early microglial dysfunction in Alzheimer's disease (AD). The project will integrate novel explainable AI techniques with human-induced pluripotent stem cell (iPSC) models to better distinguish AD-specific microglial pathways from general aging processes. It aims to uncover subtle microglial changes occurring early in...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
The National Institute on Aging (NIA) awarded a $125,896 Project Grant under the Aging Research program (CFDA 93.866) to The Washington University in St. Louis to conduct research on Alzheimer's disease (AD) risk and resilience pathways. The project aims to perform deep molecular characterization of AD genetic risk factors and protective mechanisms using state-of-the-art single-cell multi-omic analyses of healthy and AD human brain tissue, as well as transgenic AD mouse models. Key objectives...
The National Institute on Aging (NIA) awarded a $828,534 Cooperative Agreement under the Aging Research federal grant program (CFDA 93.866) to the University of Massachusetts Medical School (UMass Medical) to conduct a molecular dissection of the neuronal-adaptive immune-genomic axis. The goal is to identify novel integrative factors contributing to Alzheimer's disease (AD) pathogenesis or to the protection of brain neurons in the aging process. The project will apply large-scale, innovative,...
This Federal Project Grant award of $154,748 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop an ultrasensitive blood-based diagnostic tool for Alzheimer's disease (AD). The grant recipient, Brigham & Women's Hospital Inc., will work closely with Dr. David Walt at the Wyss Institute to create a pipeline for efficiently isolating extracellular vesicles (EVs) from plasma and quantitatively assessing the phosphorylation state of AD biomarkers using Single...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $926,389 to Wake Forest University Health Sciences (WFUHS) to conduct a clinical PET imaging study using the radiotracer [11C]MPC-6827 to evaluate microtubule integrity as an early biomarker of Alzheimer's disease progression. The study will enroll 75 participants, including cognitively normal adults, cognitively normal adults with positive amyloid PET scans, and adults with mild...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), is funding a $745,092 research project conducted by the University of Virginia. The project aims to elucidate the role of RNA modification, specifically N6-methyladenosine (m6A), in the pathogenesis of Alzheimer's disease and related tauopathies. Key objectives include decoding the epitranscriptomic profiles impacted by tau pathology, determining the role of RNA methylation in...