This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $794,341 to the University of Illinois to investigate the roles of cellular senescence and blood-brain barrier dysfunction in Alzheimer's disease development and progression. The key objectives are to understand how viral and bacterial infections can initiate blood-brain barrier impairment and increase inflammation, leading to accelerated Alzheimer's disease pathology. The research...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $437,875 to the University of California, San Diego to conduct research on neurovascular protein lifetimes in health, aging, and Alzheimer's disease. The project aims to generate a comprehensive atlas of neurovascular protein lifetimes in these conditions, with the goal of advancing the understanding of molecular mechanisms underlying neurovascular function and dysfunction associated...
This federal Project Grant award, with ID R21AG089503, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866). The $682,000 grant will fund research to investigate the influence of microglial cell depletion and repopulation on amyloid-related imaging abnormalities (ARIA) and vascular lesions in APOE4 carriers with Alzheimer's disease, following treatment with the recently FDA-approved antibody therapy aducanumab. The key products and services to be...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the adverse cerebrovascular responses to antibodies targeting beta-amyloid, a key mechanism believed to contribute to Alzheimer's disease pathology. The $2,342,415 grant awarded to the University of California, Irvine will fund a 3-year research project with the following key objectives: Examine the temporal sequence of blood-brain barrier dysfunction, myeloid cell activation, and...
This federal Project Grant award from the National Institutes of Health (NIH) National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,119,771 to the University of Massachusetts Medical School (UMass Medical) to investigate the role of peripheral insulin resistance and inflammation in Alzheimer's disease (AD) pathogenesis. The key objectives are to: 1) Define age-related changes in metabolism and inflammation in peripheral organs and the brain during AD-relevant neurodegeneration...
The University of Missouri System was awarded a $392,026 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to develop an innovative approach for treating Alzheimer's disease (AD). The key product being delivered is a novel therapeutic intervention that aims to systematically and sustainably elevate nicotinamide adenine dinucleotide (NAD+) levels in the body to counteract NAD+ decline associated with AD progression. The project will utilize a helper-dependent...
This federal Project Grant award, funded by the National Institute on Aging (part of the Department of Health and Human Services) under the Aging Research program (CFDA 93.866), is focused on evaluating a novel therapeutic approach to target neuroinflammation for protecting against brain aging and Alzheimer's disease-related pathology. The $281,962 award, with an end date of June 30, 2026, will support a series of preclinical studies in aging wild-type mice and transgenic mouse models of amyloid...
This Project Grant award, totaling $10,847,672, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The grant will fund a multidisciplinary research effort to elucidate the molecular and cellular mechanisms underlying cerebral amyloid angiopathy (CAA) and its relationship to Alzheimer's disease pathology. Key aspects include...
This $460,625 Project Grant awarded by the National Institute on Aging under CFDA Program 93.866 (Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease. The grant supports research using human induced pluripotent stem cell-based Alzheimer's disease models to dissect the functional consequences of activating the p53/p21 and p16 senescence pathways in differentiated cortical neurons and cerebral organoids. The goal is...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research provides $2,288,327 to the University of California, San Diego (UCSD) to investigate early determinants of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patients. The research aims to better understand the intersection of polygenic risk factors, biological aging, and key molecular pathways that initiate and drive MCI, with the goal of...