This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $3,038,050 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to study the molecular mechanisms of Alzheimer's disease. The funded research aims to discover a novel oxidative stress pathway that targets microglia, the immune cells in the brain, leading to their dysfunction and detrimental consequences in Alzheimer's disease. The goal is to develop...
The National Institute on Aging (NIA) awarded a $442,357 Project Grant under the Aging Research program (CFDA 93.866) to the Research Foundation of the City University of New York (RFCUNY) on December 15, 2024. The grant aims to elucidate the molecular mechanisms that give rise to functionally neurodegenerative microglia, the brain's primary innate immune cells, which have been implicated as major determinants of Alzheimer's disease (AD) risk. The research will leverage novel mouse models and...
The National Institute on Aging (NIA) awarded a $828,534 Cooperative Agreement under the Aging Research federal grant program (CFDA 93.866) to the University of Massachusetts Medical School (UMass Medical) to conduct a molecular dissection of the neuronal-adaptive immune-genomic axis. The goal is to identify novel integrative factors contributing to Alzheimer's disease (AD) pathogenesis or to the protection of brain neurons in the aging process. The project will apply large-scale, innovative,...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This $6,226,692 project grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support research to examine the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the development of Alzheimer's disease (AD). The primary focus is on investigating how modifications in brain activity, particularly in the locus coeruleus (LC) and hippocampus (HPC) regions, can lead to the key pathological hallmarks of AD....
This Project Grant award from the National Institute on Aging (NIA), part of the Aging Research program (CFDA 93.866), provides $622,086.00 to The Johns Hopkins University to conduct research on the role of the NOD2/RIPK2 signaling pathway in neuroinflammation and neurodegeneration in Alzheimer's disease. The 5-year project aims to elucidate the mechanisms of microglial activation by amyloid-beta oligomers, assess the involvement of the NOD2/RIPK2 pathway, determine the impact of selectively...
The National Institute on Aging (NIA) awarded a $842,175 Project Grant under the Aging Research program (CFDA 93.866) to the J. David Gladstone Institutes in San Francisco, CA. The grant, awarded on December 15, 2024, will fund research to explore the role of the NOX2 enzyme in mediating Alzheimer's disease (AD) pathologies, including network hyperactivity, glucose hypometabolism, and accumulation of amyloid-beta and tau proteins. The research aims to assess the therapeutic efficacy of a novel...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $314,000.00 to investigate the mechanisms by which the complement system, specifically complement C1Q, contributes to synapse loss in Alzheimer's disease (AD). The primary objectives are to: Identify potential C1Q-binding partners at synapses that may facilitate C1Q-mediated synaptic pruning in the presence of pathological tau proteins associated with AD. Determine the effect of...
The National Institute on Aging (NIA), under its Aging Research Federal Grant Program (CFDA 93.866), awarded a $4,622,818 Cooperative Agreement to investigate proteomic biomarkers for cognitive and brain changes prior to the onset of Alzheimer's disease and related dementias (AD/ADRD). The project will measure 7,000 proteins and established AD/ADRD biomarkers in the Lothian Birth Cohort 1936, a well-characterized longitudinal study, at ages 73, 76, 82, and 85. The research aims to identify...
The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $1,684,689 project grant to Weill Medical College of Cornell University to study the role of microglial lysosomes in the degradation of amyloid-beta, a key pathological feature of Alzheimer's disease. The 3-year project aims to characterize the process of "digestive exophagy" used by microglia to limit the expansion of amyloid-beta plaques, as well as explore the effects of genetic...