Project Grant R01NS152092
- The National Institutes of Health Office of the Director awarded $471,000 to Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, on August 15, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to support Project Grant R01NS144283 investigating astrocyte-based mechanisms of organophosphate poisoning. The award funds research examining how astrocytes—glial cells abundant in the brain—contribute to injury from acute organophosphate exposure,...
- Federal Project Grant Award Summary The University of Alabama at Birmingham received a $1.34 million Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 1, 2025, through August 31, 2028. The grant supports a three-year research investigation into the mechanisms of delayed lung injury following exposure to trivalent arsenic chemical agents, including lewisite, phenyl arsenic...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Tennessee Health Science Center a $3.08 million Project Grant under the Aging Research program (CFDA 93.866) for the period September 1, 2025, through August 31, 2029. This award supports research that maps genetic vulnerability to oxidative stress (OS) in development and investigates its consequences in age-associated cognitive decline. The research leverages a novel reduced-complexity rat...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $711,256 to the University of Arizona on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research defining how neurons drive outcomes in CNS toxoplasmosis caused by Toxoplasma gondii. The research addresses a mechanistic gap in understanding neuron-T....
- The National Institutes of Health Office of the Director awarded University of Alabama at Birmingham $408,373 under the Trans-NIH Research Support program (CFDA 93.310) on September 1, 2026, for a project grant (R21AR087354) investigating the cGAS-STING pathway as a mechanism-based medical countermeasure for vesicant skin injury caused by arsenical chemical agents. The award funds research using murine models to test whether arsenicals trigger skin inflammation and blistering through Type-I...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Iowa State University of Science and Technology $393,447 on July 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate disease-modifying effects of NRF2 activators in organophosphate nerve agent exposure models. The research tests whether combining neuroprotectants with current medical countermeasures will prevent long-term neurotoxicity and epilepsy development...
- The National Institute of Environmental Health Sciences awarded New York University $497,998 on June 2, 2026, to investigate the epigenetic and genetic regulation of arsenic methylation and arsenic-related cardiovascular disease risk in Native American populations under the Environmental Health program (CFDA 93.113). The research examines how DNA methylation and microRNAs influence arsenic biomethylation efficiency and downstream cardiovascular disease risk, leveraging biospecimens and...
- The National Institutes of Health Office of the Director awarded Texas A&M University System Health Science Center $423,500 on June 12, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate 2-deoxyglucose therapy as an adjunct neuroprotectant to midazolam in mitigating long-term neurological effects from acute organophosphate pesticide and nerve agent exposure. The project seeks to identify glycolysis inhibition as a novel countermeasure by testing the...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded Tulane University $625,392 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of microglial activation and inflammatory cytokine secretion as mechanisms driving central nervous system consequences of intermittent pathogen exposure. The recipient will investigate viral...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Yale University $667,613 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining ferroptosis—iron-induced programmed cell death—in erythrocytes within intracerebral hemorrhage hematomas. The project investigates how heme induces...
The National Institutes of Health Office of the Director awarded the University of Tennessee Health Science Center $403,972 under the Trans-NIH Research Support program (CFDA 93.310) on August 15, 2026, to define mechanistic pathways through which arsenic trioxide disrupts brain and cognitive function and to identify novel therapeutic strategies to prevent or mitigate delayed neurotoxic consequences of exposure. Research focuses on the integrated stress response and stimulator of interferon genes signaling pathways as key drivers of arsenic trioxide-induced neurodegeneration, building on prior transcriptomic and molecular profiling that identified these mechanisms as central to how the chemical elevates serum heme levels and triggers stress responses in human induced pluripotent stem cell-derived neurons and mouse brains. The award period runs through July 31, 2029, with performance in Memphis, Tennessee.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $404.0k | 8/14/26 |