Project Grant R01NS150461
- The National Institute of Neurological Disorders and Stroke awarded Brown University $473,561 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of endoplasmic reticulum membrane contact sites in synapse formation and plasticity. The award funds research on PDZD8, an endoplasmic-reticulum-resident tethering protein linked to intellectual disability that regulates activity-dependent...
- The National Institute of Neurological Disorders and Stroke awarded The University of Texas Southwestern Medical Center $464,188 on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate mechanisms of neurotransmitter release regulation by the protein munc13-1. The research examines how munc13-1 orchestrates assembly of SNARE protein complexes that fuse synaptic vesicle and plasma membranes, enabling...
- The National Institute of Neurological Disorders and Stroke awarded the University of Rochester $1,606,088 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate spatiotemporal control of cerebral blood flow by purinergic signaling networks. The project examines neurovascular coupling—the process by which cerebral blood flow rapidly directs to active brain regions to meet metabolic demands—with specific focus...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $126,900 on March 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to exploit RNA biogenesis, specifically alternative splicing programs, to accelerate maturation of human neurons in vitro and to develop models of age-related tauopathies. The research addresses a fundamental...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $589,156 on February 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project investigates s-palmitoylation as a regulatory mechanism for CAV2.1 and CAV2.2 calcium channels in presynaptic neurons. These channels mediate calcium influx that triggers neurotransmitter release at chemical synapses and...
- The National Institute of Neurological Disorders and Stroke awarded The Rockefeller University $630,609 on July 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate glial cell roles in preserving dendrite integrity following neuronal injury. The research explores how glial cells sense and respond to damage in neuronal dendritic structures and substructures, including dendritic spines and sensory neuron cilia. The...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $619,580 on April 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on neuronal kinase signaling in health and disease. The project integrates AI/ML algorithms, CRISPR-based proteomics, and in vivo models to investigate how kinases regulate neuronal physiology and contribute to neurodegenerative disease, with specific focus on...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded Drexel University $547,255 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of the functional organization of descending neuron networks that control collision-avoidance behavior. Using electron microscopy connectomes of the central nervous system at synaptic...
- The National Institute of Neurological Disorders and Stroke awarded New York University $466,125 on September 25, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop genetic approaches for studying the organization and function of neocortical layer 1. The research examines how top-down information streams (behavioral saliency, expectations, predictions, and memories) integrate with bottom-up sensory information in the...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $126,900 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research dissecting the synaptic and molecular mechanisms of cell-type-specific memory computation in the hippocampal CA3 network. The award funds in vivo imaging, genetic perturbations, transcriptomics, and computational...
The National Institute of Neurological Disorders and Stroke awarded New York University $550,743 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to fund research into the mechanisms of assembly of endocytic machinery at the periactive zone and its coupling to the presynaptic active zone. The research dissects how the large GTPase dynamin organizes both the active zone, where neurotransmitters are released from synaptic vesicles, and the periactive zone, where the endocytic apparatus restores vesicles for subsequent rounds of neurotransmission. The project builds on pilot data showing that dynamin deletion selectively eliminates active zone proteins MUNC13-1 and RIM, decreases neurotransmitter release, and disrupts the spatial segregation of endocytic proteins in clusters at the periactive zone. The work will investigate how dynamin bridges these two functionally interdependent membrane compartments, with implications for understanding brain disorders linked to components of both machineries. Work is performed at New York University School of Medicine in New York, New York. The period of performance runs from August 15, 2026 through July 31, 2031. This is a Project Grant, an assistance type supporting hypothesis-driven research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $550.7k | 8/11/26 |