Project Grant R01NS141351
- This Project Grant award of $567,037.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to characterize the synchrony between peripheral nerve post-injury activity and brain plasticity. The research will utilize an innovative optical imaging method to simultaneously monitor nerve regeneration and corresponding changes in the cerebral cortex in mice...
- This Project Grant award of $129,717 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate the role of neutrophils in the pathology of amyotrophic lateral sclerosis (ALS). The research, conducted by the Regents of the University of Michigan, aims to identify neutrophil subpopulations and mechanisms associated with ALS progression and...
- This Project Grant award of $1,188,230 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to evaluate the cellular composition, activation state, and spatial niches involved in neuroma formation following severe peripheral nerve injuries. The primary goals are to validate preliminary data indicating that neutrophil extracellular traps (NETs) may be an...
- This $341,958 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to investigate the regulation of nociceptor excitability by Macrophage Migration Inhibitory Factor (MIF) as a potential therapeutic strategy for treating chronic neuropathic pain after spinal cord injury (SCI). The 5-year research project, awarded to the University of Texas Health Science...
- This $475,369 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand how microglia (the brain's resident macrophages) are programmed by the brain environment following transplantation. The primary awardee, The Trustees of the University of Pennsylvania, will use single-cell RNA and ATAC sequencing to...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded Kenyon College a Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $454,424 grant, effective April 1, 2025 through March 31, 2028, aims to characterize the cellular and molecular mechanisms of Schwann cell demyelination and identify factors that promote peripheral remyelination using a novel larval zebrafish model. The project will test...
- This $540,322 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at The Ohio State University on the role of 3D chromatin architecture in axonal regeneration following peripheral nerve injury. The objective is to investigate how the folding of the genome into topologically associating domains (TADs) and enhancer-promoter...
- This federal Project Grant award for $659,325.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to understand the role of mutant IDH1 in glioma pathophysiology and immune response mechanisms. The research will use a novel murine glioma model developed by incorporating genetic lesions into neural progenitor cells using the...
- This Project Grant award of $409,887.00 from the National Institute of Neurological Disorders and Stroke (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to investigate the mechanisms leading to small fiber neuropathy and loss of epidermal nerve fibers. The research aims to explore whether epidermal axons comprise a surveillance network that responds to threats on body surfaces, leading to nerve fiber density loss. Key areas...
- This $424,875.00 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund a comprehensive study of gene transcription patterns in diverse classes of neurons that connect the brain to the spinal cord after spinal cord injury in a mouse model. The research team at Marquette University will use single-cell sequencing technologies to profile...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports scientific research focused on understanding the immune response to peripheral nerve injury in mice. The $531,478 award to the Regents of the University of Michigan will fund a longitudinal analysis combining flow cytometry and single-cell RNA sequencing to explore the distinct and location-specific immune milieus at the site of injury and in the distal nerve. Key objectives include differentiating the roles of blood-borne monocyte-derived macrophages and tissue-resident macrophages, as well as analyzing changes in the metabolic state and inflammatory profiles of these macrophage subpopulations. The research aims to advance the understanding of how immune cells regulate processes like nerve debridement, angiogenesis, axon regeneration, and pain following peripheral nervous system trauma.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $531.5k | 7/28/25 |