Project Grant R01NS146597
- The National Institute of Neurological Disorders and Stroke awarded the University of Alabama at Birmingham $237,870 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to localize cerebral epileptiform activity during stereoelectroencephalography monitoring. Approximately one-third of epilepsy patients are drug-resistant and candidates for surgical intervention. Successful epilepsy surgery depends on accurate localization...
- The National Institute of Neurological Disorders and Stroke awarded the University of Alabama at Birmingham $186,250 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate machine-learning seizure risk prediction models for newborns. The project, titled Prediction of Risk of Infant Seizures Using Machine Learning (PRISM), addresses a critical gap in neonatal seizure detection. Existing automated...
- The National Institute of Neurological Disorders and Stroke awarded the University of Alabama at Birmingham a $644,394 cooperative agreement on May 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) to conduct a controlled first-in-human assessment of spinal cord stimulation as a treatment for primary, treatment-resistant restless legs syndrome. The research will evaluate the safety, patient acceptance, and preliminary...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded the University of Alabama at Birmingham $186,250 on January 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into AMPA receptor function at interneuron synapses in the hippocampus. The work examines how presynaptic mechanisms contribute to the...
- The National Institute of Neurological Disorders and Stroke awarded Baylor College of Medicine $100,228 on September 30, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop optimized neurostimulation patterns for seizure control in drug-resistant epilepsy. The recipient will design and validate a novel platform combining high-entropy stimulus generation and deep learning to optimize complex pulse sequences with...
- The National Institute of Neurological Disorders and Stroke awarded the University of Pennsylvania $646,295 on June 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, R01NS148413) to develop quantitative methods for measuring seizure spread and interictal abnormalities on scalp and intracranial electroencephalography (EEG) to improve identification of focal versus diffuse epileptic networks and guide surgical planning for...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $555,895 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the biophysical mechanisms of temporal interference stimulation on epileptic discharges in the human brain. The research, conducted at the Comprehensive Epilepsy Center at Duke University in Durham, North Carolina, will leverage stereo-electroencephalography...
- The National Institute of Neurological Disorders and Stroke awarded the University of Louisville $564,010 on August 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate ventral pallidum deep brain stimulation as a treatment for refractory epilepsy. The research tests whether deep brain stimulation of the ventral pallidum—a basal ganglia structure—prevents spontaneous recurrent seizures and mitigates...
- The National Science Foundation Office of International Science and Engineering awarded the University of Alabama at Birmingham $1,026,784 on September 1, 2026, under the Office of International Science and Engineering program (CFDA 47.079) to develop and validate large-scale computational models of thalamo-cortical neural networks and test them against intracranial electroencephalographic recordings and deep brain stimulation data from patients undergoing epilepsy monitoring and general...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the University of Alabama at Birmingham $100,000 on July 15, 2026, under the Engineering program (CFDA 47.041) to investigate single-neuron computational mechanisms of visual object coding in the human brain. The research combines intracranial single-neuron recordings, eye tracking, and computational modeling to uncover how individual brain cells in the medial temporal lobe...
The National Institute of Neurological Disorders and Stroke awarded the University of Alabama at Birmingham $567,358 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop single-pulse electrical stimulation (SPES) protocols for improving surgical outcomes in drug-resistant epilepsy. The project addresses limitations in current SPES clinical utility by applying dynamical systems and control theory to enhance localization of epileptogenic networks and increase post-surgical seizure freedom. The research comprises two phases. The first phase compares localization efficacy of SPES-evoked biomarkers against established interictal biomarkers in a retrospective cohort of 124 patients from four Level 4 epilepsy centers: University of Alabama at Birmingham, New York University, Johns Hopkins University, and the University of Pennsylvania. The second phase optimizes SPES parameters—including pulse amplitude, pulse width, and polarity—in a prospective cohort of 50 patients at UAB to identify robust parameters for localizing hyperexcitable brain regions. Place of performance is Birmingham, Alabama. The period of performance runs from September 1, 2026, through July 31, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $567.4k | 8/31/26 |