Project Grant R01NS146544
- Federal Project Grant Award Summary Van Andel Research Institute (VAI) received a Project Grant award of $1,009,212 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective July 4, 2025, with completion targeted for June 30, 2027. The award supports research and development activities focused on a novel gene therapy approach to mitigate neurotoxicity in...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Van Andel Research Institute $123,163 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) Project Grant program, with an award date of June 1, 2025 and completion date of September 26, 2025. This research initiative focuses on identifying cortical neuronal vulnerability and resilience in Parkinson's disease through advanced molecular and genomic...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Van Andel Research Institute a Project Grant of $555,128 on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The research will be conducted through January 31, 2031, at the institute's facility in Grand Rapids, Michigan. This project investigates the mechanisms underlying C9ORF72-associated frontotemporal...
- Federal Grant Award Summary Van Andel Research Institute received a $528,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 9, 2025, with completion targeted for May 31, 2030. The research project aims to reveal the molecular basis of microtubule-intermediate filament interactions, specifically focusing on how these cytoskeletal components are adapted and regulated...
- Summary of Federal Project Grant Award The National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded Van Andel Research Institute (VAI) a project grant of $288,000 with an award date of August 4, 2025, and an ultimate completion date of July 31, 2027. This two-year project grant supports research into fatty acid metabolism in disease models of mitochondrial fatty acid synthesis (MTFAS)...
- Federal Project Grant Award Summary Rockefeller University received a $220,260 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, through July 31, 2030. This research grant supports a five-year investigation into RNA regulation mechanisms in striatal neurons affected by Parkinson's disease. The project focuses on...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Johns Hopkins University a $155,000 project grant effective July 8, 2025 through June 30, 2027 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The award supports the characterization of an aminoacyl-tRNA synthetase complex interacting multifunctional protein-2 (AIMP2) variant-linked mouse model of Parkinson's disease. The...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $196,588 to Icahn School of Medicine at Mount Sinai under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program on May 1, 2025, with a completion date of April 30, 2027. This Project Grant supports basic neuroscience research investigating midbrain neuronal vulnerability in Parkinson's Disease (PD). The research will employ single-nucleus RNA...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $227,205 Project Grant award dated May 9, 2025, from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research project, which extends through April 30, 2030, examines the effects of the Parkinson's Disease-associated protein LRRK2 (leucine-rich repeat kinase 2) on lysosomal...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded UCLA a $460,563 Project Grant effective August 1, 2025 through July 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). This research project will investigate ProSAAS, a brain-specific cellular chaperone protein, as a therapeutic intervention for Parkinson's Disease. The research will focus on developing an inducible nuclear protein...
Van Andel Research Institute (VAI) received a $582,465 Project Grant award on March 15, 2026, from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The grant supports a research project investigating the neurodegenerative mechanisms of ATP13A2-linked Parkinson's Disease and Kufor-Rakeb Syndrome, with performance activities conducted in Grand Rapids, Michigan through February 28, 2031. The project deliverables include mechanistic research utilizing a newly developed adult-onset ATP13A2 conditional knockout mouse model to elucidate how loss-of-function mutations in the ATP13A2 gene compromise polyamine transport, lysosomal function, and dopaminergic neuronal survival in disease-relevant neuronal populations and animal models. The research outputs are intended to advance understanding of the pathophysiology underlying ATP13A2-related neurodegenerative disorders and facilitate the development of novel disease-modifying therapeutic strategies for conditions currently lacking such treatments. As a nonprofit biomedical research organization with established expertise in neurodegenerative disease research and molecular biology, VAI provides the scientific infrastructure, advanced research capabilities, and investigator expertise necessary to execute this basic and translational neuroscience investigation funded through NINDS's peer-reviewed competitive grant mechanism.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $582.5k | 3/10/26 |