Project Grant R01NS145443
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...
- This Project Grant award for $453,860.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the metabolic regulation of neutrophil extracellular traps (NETs) in traumatic brain injury (TBI). The research aims to elucidate how AMPK activation protects the brain by reducing NET formation and inflammation following TBI, with the goal...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $157,486 project grant to Case Western Reserve University (CWRU) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The project aims to investigate the interplay between traumatic brain injury (TBI), hematopoietic stem cell (HSC) dysfunction, chronic neurodegeneration, and Alzheimer's disease (AD). Specifically, the research will assess how acute TBI induces...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders" provides $404,100.00 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to study the mechanisms of chronic blood-brain barrier dysfunction after traumatic brain injury (TBI). The research aims to identify a signaling pathway involving the...
- This $380,556 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research at East Carolina University to investigate the regulation of efferocytosis, the process of phagocytes removing apoptotic cell debris, in the brain following traumatic injury. The research aims to determine the temporal dynamics of...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $465,752 to the Regents of the University of Michigan - Dearborn to conduct research on understanding changes in cell chirality and cell-cell interactions within the neurovascular unit (NVU) after traumatic brain injury (TBI). The project aims to evaluate TBI-induced...
- This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at The Ohio State University on the role of NF-kB in chronic inflammation, microglia priming, and neuropsychiatric complications following traumatic brain injury (TBI). The $132,609 award, which runs from September 1, 2025 to April 30, 2027, aims to explore...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $571,404.00 to the University of Pittsburgh to conduct research on the use of the adipokine hormone adiponectin as a potential therapy to promote functional recovery after traumatic brain injury (TBI). The funding will support investigations into the long-term impact and...
- This Project Grant award of $559,820 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research by the University of South Carolina to characterize the biomechanical response of the human brain during traumatic brain injury (TBI). The research aims to integrate dynamic MRI and sonomicrometry techniques to measure brain deformation at both low and high...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Texas Tech University Health Sciences Center (TTUHSC) is intended to investigate the biological mechanisms underlying the development of age-related diseases following traumatic brain injury (TBI). The $192,737 award, effective April 15, 2025 through March 31, 2028, will support research focused on understanding how interactions between the TBI biomarker UCHL1 and prostaglandins contribute...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $654,218 to the University of Maryland, Baltimore to support research on the mechanisms and intervention of cyclic GMP-AMP synthase (cGAS) signaling in traumatic brain injury (TBI). The research aims to investigate how the leakage of genomic and mitochondrial DNA into the brain after TBI activates the cGAS signaling pathway, leading to neuroinflammation and neurodegeneration. The project seeks to advance the understanding of the role of cGAS-mediated cellular senescence in TBI pathogenesis. This 5-year research project is expected to run from August 1, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $654.2k | 7/29/25 |