Project Grant R01NS143962
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pittsburgh a Project Grant of $109,062.00 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant, effective August 7, 2025, through July 31, 2030, funds a predoctoral training program in basic neuroscience at the Center for Neuroscience at the University of Pittsburgh (CNUP). This award replaces an expired T32...
- Federal Grant Award Summary The University of Pittsburgh received a $2.35 million Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded on September 8, 2025, with a completion date of June 30, 2029. This research initiative investigates the pathological mechanisms underlying blood-cerebrospinal fluid (CSF) barrier dysfunction in vascular cognitive...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pittsburgh $416,544 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program on June 1, 2025, with completion anticipated by May 30, 2027. This Project Grant supports the development and validation of novel non-invasive imaging tools for evaluating therapeutic efficacy in Leigh Syndrome, a severe childhood-onset...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $1,004,971 Project Grant to the University of Pittsburgh under the Mental Health Research Grants program (CFDA 93.242) on April 8, 2026, with a completion date of February 28, 2029. The award supports "A Day in the Life of the Human Brain: Investigating the Dynamic Interrelationship Between Brain, Cognition, Behavior, and Physiology," a research initiative designed to address a critical knowledge gap...
- Federal Grant Award Summary The University of Pittsburgh received a $620,504 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded February 11, 2026, with completion targeted for November 30, 2030. The award funds research investigating how the lateral parabrachial nucleus (LPBN) functions as a neural hub that integrates competing survival...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $224,265 to the University of Pittsburgh under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 1, 2025, through July 31, 2030. This Career Development Award supports the development and refinement of novel interventions to improve neurological prognostication for patients with hypoxic-ischemic brain injury...
- Federal Project Grant Summary Carnegie Mellon University received a $1,125,953 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded August 1, 2025, with completion scheduled for April 30, 2030. This grant supports fundamental neuroscience research investigating interhemispheric coordination mechanisms for memory and action. The research addresses...
- Federal Project Grant Award Summary The University of Pittsburgh received a $566,936 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded June 12, 2025, with completion expected February 29, 2028. This research initiative targets the characterization of orexinergic neural projections from the hypothalamus to the spinal cord as a potential...
- Federal Grant Award Summary The University of Pittsburgh received a $664,619 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. This award supports comprehensive research into multiscale models of age-specific neurometabolic coupling, with a focus on understanding the relationship between neuronal activity and metabolic processes in late-onset Alzheimer's disease. The research deliverables...
- Federal Grant Award Summary The University of Pittsburgh received a $437,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded May 5, 2026, with completion targeted for January 31, 2031. The award funds development of a generalizable computational platform that integrates systemic omics data (proteomics, metabolomics, and transcriptomics), imaging-derived phenotypes, and genetic...
Federal Grant Award Summary The University of Pittsburgh received a $624,368 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective May 15, 2026, through April 30, 2031. This research award supports a comprehensive investigation into the neural basis of brain resting state activity, with the primary objective of elucidating the relationship between spontaneous brain activity, cortical architecture, and cortical neurophysiology. The research employs non-human primate models to deploy high-resolution neuroimaging and neurophysiological recording tools, combining functional magnetic resonance imaging (fMRI), intrinsic signal optical imaging (ISOI), and microelectrode mapping to advance understanding of how the brain's structured spontaneous activity relates to underlying anatomical and functional organization. The research delivers critical neuroscientific knowledge intended to improve the validity and utility of resting-state fMRI as a diagnostic and research tool for understanding brain organization in health and disease. By establishing ground-truth correlations between resting-state imaging patterns and actual cortical divisions—validated through high-resolution mapping in motor and somatosensory regions—this project addresses a significant knowledge gap that currently limits the interpretive capacity of hundreds of annual studies and substantial National Institutes of Health investments in brain mapping initiatives such as the Human Connectome Project. The findings are expected to enhance the neurobiological foundation underlying brain organization research and strengthen inferences drawn from resting-state neuroimaging across clinical and research applications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $624.4k | 5/11/26 |