This Project Grant award of $244,154, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at the Albert Einstein College of Medicine to investigate the regulation of presynaptic gene transcripts during synaptogenesis. The research, conducted over the period from September 1, 2024 to June 30, 2027, will leverage the genetic accessibility and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $249,750 to the University of Connecticut Health Center to conduct research on the molecular mechanisms by which the synaptic protein C1QL3 promotes excitatory synapse formation and function. The key objectives are to elucidate the structural basis for C1QL3's transsynaptic...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $551,250 to the University of California, Los Angeles (UCLA) to conduct research on the molecular mechanisms underlying the formation of synaptic connections between neurons in the brain. The key objectives of this 1-year award, which runs from June 1, 2025 to May 31, 2026, are...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $404,340 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Georgia Research Foundation, Inc. The project aims to develop a novel method using split fluorescent protein tags to map the localization of neurotransmitter receptors within neural circuits in the Drosophila model organism. This work will provide crucial new insights into the...
This federal Project Grant award of $660,632 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research aimed at understanding the structure and dynamics of the fusion pore, a critical component of the membrane fusion process that underlies neuronal function. The key objectives of the research are to: 1) leverage a novel reconstituted system to...
This federal Project Grant award under the National Institute of Neurological Disorders and Stroke's (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $471,402 to Yale University to conduct research on the role of the Kv3.4 potassium channel in neuronal development. The research aims to investigate how the binding of Kv3.4 to the cell adhesion molecule Protocadherin 9 (PCDH9) affects the formation of filopodia and neurite outgrowth. The...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to develop a chemical strategy for light microscopy-based imaging of neural synapses and circuit connectivity in post-mortem specimens, including potentially the human brain. The $235,887 award, with a project period from April 1, 2025 to March 31, 2027, will be...
This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...
This federal Project Grant award of $565,257.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to understand how presynaptic modulation of synaptic inhibition onto hippocampal pyramidal neurons in the brain regulates spatial information encoding. Key objectives include determining how metabotropic glutamate receptor...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $488,507 to the University of California, Irvine to conduct pre-clinical translational studies on targeting synaptic dysfunction in lissencephaly, a severe brain malformation. The research aims to investigate whether glutamatergic synapses can be targeted as a disease-modifying...