Project Grant R01NS142590
- This federal Project Grant award of $770,502.00, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the molecular mechanisms by which collagen IV regulates TGF-beta signaling and its role in cerebral small vessel disease (CSVD). The research will use mouse models to perform intravital imaging of the cerebral vasculature and...
- This Project Grant award of $671,775.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to elucidate the molecular mechanisms and therapeutic potential of SLC4 bicarbonate transporters expressed in the brain. The project aims to combine structural studies, computational modeling, in silico drug discovery, and validation in cell-based and animal models to...
- This federal Project Grant award, titled "Structural and Functional Insights into Large-Pore Channels", was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The $732,475 award, effective from August 1, 2025 to April 30, 2030, supports research conducted by Cold Spring Harbor Laboratory to enhance the understanding of calcium homeostasis...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $125,724 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Regents of the University of California, San Francisco (UCSF) on January 23, 2025. The project, titled "Hypoxia-Induced Misdirection: Understanding Postnatal Inhibitory Interneuron Migration in Neonatal Hypoxic Injury", aims to use computational approaches to identify altered...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,008,977.00 to the Regents of the University of California, San Francisco to conduct research on the developmental topology of the human cerebral cortex. The key objectives are to understand human brain development and the origins of neurodevelopmental diseases by studying...
- The National Science Foundation awarded a $595,104 Project Grant to the University of Maryland, College Park under the Engineering program (CFDA 47.041) to support research on integrated experimental and computational models of brain microvascular endothelial cell glucose metabolism and transport from September 1, 2022 to August 31, 2025. The award will fund the development of new experimental and computational models to study how decreased membrane cholesterol affects brain microvascular...
- This federal Project Grant award of $115,327.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to investigate the protracted maturation of cortical inhibitory neurons (CINs) in the human brain and their contribution to regional cortical specification and vulnerability during the perinatal period. The research aims to...
- This Project Grant award of $427,625 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is funding research to develop a toolbox for studying proteome plasticity in brain endothelial cells. The research aims to further understand the mechanisms of brain blood flow regulation, which is critical for addressing neurological disorders like Alzheimer's disease where disruption of...
- The federal Project Grant award of $621,500 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The goal of the project is to develop new methods for combined molecular and ultrastructural imaging of neural cells and tissues using advanced nanoprobes and cathodoluminescent dyes. Specifically, the award will fund the development of (1) detergent-free...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $1,375,478 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the J. David Gladstone Institutes in California. This grant funding supports a multidisciplinary research program to study the role of neurovascular dysfunction in neurodegeneration, CNS repair, and glial cell biology. Key research activities include in vivo two-photon and super-resolution...
This $654,593 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, aims to develop structure-guiding tools to study the role of choline in the development of congenital hydrocephalus. The key objectives are: 1) Determine the structures of the FLVCR1 and FLVCR2 choline transporters using cryo-electron microscopy to generate functional hypotheses, 2) Define the mechanisms of choline transport and heme-choline interactions in brain endothelial cells and neural progenitor cells using radioactive and fluorescent tracers, and 3) Generate new mouse models with conditional mutations in FLVCR1 or FLVCR2 to test structure-function relationships in vivo. The award period is from Aug 15, 2025 to Jul 31, 2030, and the work will be performed at the University of California, San Francisco.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $654.6k | 7/30/25 |