Project Grant R01NS142427
- The National Institute of Neurological Disorders and Stroke awarded Drexel University $149,190 on July 14, 2026, under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) to conduct research on transcutaneous spinal cord stimulation and its mechanisms for reducing spasticity following spinal cord injury. The research investigates whether transcutaneous spinal cord stimulation improves spasticity after spinal cord injury by upregulating KCC2, a chloride...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $234,750 on January 26, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate neuromodulation of somato-sympathetic postganglionic activity after spinal cord injury. The research develops animal models incorporating clinically analogous epidural spinal cord stimulation to understand how neuromodulation can restore autonomic function...
- The National Institute of Neurological Disorders and Stroke awarded the University of Florida $605,411 on August 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate mechanisms of cervical epidural stimulation for respiratory recovery following spinal cord injury. The project focuses on closed-loop epidural stimulation as a neuromodulation strategy to restore diaphragm activation and promote respiratory motor...
- The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic $443,850 on June 15, 2026, for development of a practical, clinically-focused endovascular cooling system for neuroprotection in acute ischemic stroke under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project addresses limitations in current selective brain cooling approaches used alongside thrombectomy procedures for large vessel occlusions. Existing...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $660,613 to The Trustees of Columbia University in the City of New York on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research on spinal cord stimulation as a combination therapy to enhance motor function in spinal muscular atrophy (SMA). The research...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded The Medical University of South Carolina $226,500 on August 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to characterize spinal pain and non-pain pathway activity and responses in people with chronic spinal cord injury and neuropathic pain. The research will compare...
- The National Institute of Child Health and Human Development awarded Kessler Foundation, Inc. $562,228 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct a project grant investigating transcutaneous spinal cord stimulation for blood pressure regulation and orthostatic hypotension in individuals with spinal cord injury. The study will recruit ten individuals at least one year post-spinal cord injury with orthostatic hypotension and...
- The National Institute of Neurological Disorders and Stroke (part of the Department of Health and Human Services National Institutes of Health) awarded Oregon Health & Science University $5.363 million on August 18, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to optimize spinal cord stimulation parameters for pain and itch management. The research investigates how epidural spinal cord stimulation engages dorsal horn circuits, specifically targeting neuropeptide Y...
- The National Institute of Neurological Disorders and Stroke, a division of the Department of Health and Human Services National Institutes of Health, awarded The Ohio State University $586,866 on May 6, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate a cellular transplantation therapy for cervical spinal cord injury using human induced pluripotent stem cell-derived deep cortical neurons. The recipient will...
- The National Heart, Lung, and Blood Institute awarded Mayo Clinic $593,663 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate thrombolysis resistance in acute ischemic stroke with large vessel occlusion. The project addresses the failure of intravenous thrombolysis with tissue plasminogen activator (TPA) to achieve successful recanalization in most eligible patients. Mayo Clinic will conduct three integrated research activities: define metabolic...
The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic $622,784 on July 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate acute and chronic repercussions of spinal cord stimulation following spinal cord injury. The research quantifies blood pressure instability after spinal cord injury, which interrupts descending autonomic regulatory signals and causes loss of consciousness, stroke, and death. Mayo Clinic's work applies a laboratory-based autonomic testing battery to determine whether acute or chronic spinal cord stimulation—delivered transcutaneously or epidurally—stabilizes blood pressure regulation through the injured spinal cord. Prior case studies showed acute spinal cord stimulation increases blood pressure when sympathetic activation is needed, but the mechanism and broader repercussions remain unknown. Pilot studies suggest both acute transcutaneous and epidural stimulation increase static sympathetic activation to raise blood pressure but do not improve autonomic regulation as theorized; chronic stimulation may facilitate intact regulatory mechanisms like the baroreflex to stabilize blood pressure and mitigate autonomic drivers of immunosuppression and cardiovascular disease. Work is performed in Rochester, Minnesota. The period of performance runs from July 21, 2026, through May 31, 2031. This is a Project Grant, the standard assistance type for NIH extramural research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $622.8k | 7/20/26 |