Project Grant R01NS142131
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $407,113 to the University of California, Irvine under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program on August 15, 2025, for an R21 exploratory research project extending through July 31, 2027. This project grant supports the development of novel KV7 channel modulators designed to mitigate chronic pain by preventing M-current suppression...
- Federal Project Grant Award Summary This $472,592 project grant, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to advance migraine treatment by investigating RGIA5474, a novel α9α10 nicotinic acetylcholine receptor (nAChR) antagonist. Awarded to New York Institute of Technology on August 1, 2025, for a three-year performance period...
- Federal Grant Award Summary The University of Pittsburgh received a $1.15 million Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded on March 15, 2025, with a completion date of January 31, 2030. The grant funds research to investigate the neuronal circuitry and central sensitization mechanisms underlying mechanical allodynia—a debilitating...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $372,880 to The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This project grant supports basic research investigating astrocyte calcium signaling mechanisms in chronic pain, with a performance period extending through May 31,...
- Federal Cooperative Agreement Award Summary The University of Southern California Department of Contracts and Grants received a $818,360 Cooperative Agreement from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective June 1, 2025, through May 31, 2029. The award supports the development of angiotensin AT2 receptor (AT2R) antagonists for treating neuropathic pain,...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The University of Pennsylvania a $446,875 Project Grant effective June 1, 2025, through May 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The research project focuses on generating and characterizing a novel NTRK3-FLPO knockin mouse line to enable genetic interrogation of Aβ nociceptors—a previously inaccessible population of...
- Federal Project Grant Summary Massachusetts Institute of Technology received a $591,122 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, with completion targeted for July 31, 2029. The award supports fundamental neuroscience research investigating the emotional/affective component of pain through identification and...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pennsylvania a Project Grant totaling $667,349 (awarded August 1, 2025, with completion targeted for June 30, 2030) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This research grant supports a neuroscience investigation into state-dependent control of nociception (pain sensation) in opioid circuits,...
- Federal Project Grant Award Summary Michigan State University received a $431,750 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective June 1, 2025, through May 31, 2027. The award supports research to investigate the role of CCL12, a chemokine mediator, in postoperative pain management. The project delivers preclinical research services and...
- Federal Project Grant Award Summary Middlebury College received a $540,427 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) effective August 18, 2025, with completion targeted for June 30, 2028. The award supports research to develop biologically-motivated mathematical models that explain mechanisms of interindividual variation in pain modulation through spinal cord stimulation (SCS). The...
The University of Southern California received a $415,000 Project Grant awarded February 15, 2026, by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The five-year award, with completion targeted for January 31, 2031, supports basic neuroscience research investigating the cellular mechanisms underlying cold allodynia—heightened sensitivity to cold following injury or disease. The research focuses on understanding how the menthol receptor TRPM8 (transient receptor potential melastatin 8) and associated signaling molecules, specifically artemin and its receptor GFR alpha-3, mediate diverse physiological responses to cold stimuli. The project aims to elucidate the cellular and molecular transduction mechanisms by which injury-induced sensitization of TRPM8-expressing sensory neurons leads to pathological cold pain perception and migraine-like symptoms. Findings from this investigator-initiated research have potential applications for developing targeted therapeutic interventions for cold-induced pain conditions and migraine disorders.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $415.0k | 2/3/26 |