This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders provides $499,979 to The Salk Institute for Biological Studies to conduct research on the role of astrocytes in neuropathic pain. The key objectives are to: 1) determine how peripheral nerve injury alters dorsal horn astrocyte function, 2) elucidate how targeted interventions control dorsal horn...
This $2,249,392 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to validate senescent cells as a target for the treatment of chronic pain in aging. The project aims to rigorously characterize the role of senescent neurons and their senescence-associated secretory phenotype (SASP) in driving dorsal root ganglion hyperexcitability and persistent pain following...
This Project Grant award, with a total funding amount of $664,772, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to investigate the signaling mechanisms involving the neurotensin receptor 2 (NTSR2) and voltage-gated calcium channels (Cav2.3 and Cav2.2) as a novel, non-opioid analgesic pathway for the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $560,934 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct research on neural coding and control of pain detection in the somatosensory cortex. The 5-year research project, which commenced on April 1, 2025, aims to: Define...
This federal Project Grant award, with the ID R35NS132231, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $885,128 grant supports research aimed at gaining a molecular-level understanding of the design principles governing somatosensation and nociception by membrane sensory receptor channels, as well as broader contextualization. The research, led...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $453,104 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on ascending spinal pain circuits. The key objectives are to: 1) determine the combinatorial, pathophysiological role of spinal projection neuron subtypes (TACR1- and...
This $429,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of Schwann cell PIEZO1 in pain sensation. The key objectives are to: 1) develop and validate adeno-associated virus (AAV) vectors for selective inhibition of Schwann cell PIEZO1, and 2) determine the sensory effects of Schwann cell...
This Project Grant award of $158,512 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at the University of Pittsburgh to characterize the role of orexinergic neurons in the spinal cord and their potential for treating chronic pain. The key research objectives are to: 1) use two-photon calcium imaging to investigate how orexin peptides impact the...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $246,750 to The Trustees of Columbia University in the City of New York, Health Sciences Division, to research the role of the mesocortical glutamatergic pathway in the development and maintenance of chronic neuropathic pain. The project aims to use in vivo imaging,...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $441,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Duquesne University of the Holy Spirit. The purpose of this 3-year grant, beginning September 2023, is to utilize laboratory data and computational 3-D modeling to analyze the role of the central amygdala in neuropathic pain. Specifically, the project aims to build a proof-of-concept 3-D...