Project Grant R01NS140594

Award Date 5/26/25
Completion Date 6/30/30
Dollars Obligated $481K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Illinois, USA
Similar Awards
This federal Project Grant award for $1,341,874.00 was issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research conducted by the University of California, San Francisco (UCSF) to elucidate the molecular mechanisms controlling dendrite development, function, degeneration, and regeneration. Key areas of focus include identifying the...
This federal Project Grant award for $563,343.00, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at New York University School of Medicine to investigate the physical, molecular, and cellular mechanisms underlying tissue guidance and tissue splitting during nervous system development. Specifically, the research project aims to determine...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), provides $828,335 to the University of Chicago to investigate the roles of inhibitory and disinhibitory neural circuits in the formation, stabilization, and competition of neural assemblies in the cortex. The project aims to experimentally test theoretical...
The University of Chicago was awarded a $625,000 Project Grant from the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences CFDA program. This three-year collaborative research project will elucidate the molecular mechanisms underlying the activation of ROBO receptor proteins that guide the growth and navigation of axons during neural circuit development. The research aims to determine how ROBO receptors have evolved to allow for the...
This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research focused on understanding long-distance regressive signaling processes that shape nervous system development. The $543,337 award, effective January 1, 2025 through December 31, 2029, will enable Vanderbilt University to characterize how the p75 neurotrophin...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), will support research to define the molecular mechanisms by which the DCC receptor regulates axon guidance and neuronal morphogenesis. The $576,841 award to The Trustees of the University of Pennsylvania will address key knowledge gaps in understanding how DCC signaling...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,002,148 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Regents of the University of California, Berkeley. The grant supports research aimed at understanding the molecular, structural, and biochemical mechanisms that regulate the class III phosphoinositide 3-kinase (PI3K) complexes, which play a key role in controlling neuronal autophagy....
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $481,250 to President and Fellows of Harvard College to develop a synthetic biological system for subcellular manipulation of RNAs and proteins in subtype-specific neurons. The goal is to enable investigation of the molecular mechanisms regulating neural circuit...
This $145,642 federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research into the regulation of presynaptic gene transcripts during synaptogenesis at Albert Einstein College of Medicine. The research aims to characterize the dynamics of the SYD-2/Liprin-alpha mRNA and identify novel candidates for mRNA regulation at...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $582,883 to the Regents of the University of California at Riverside to conduct research on the role of CAS adaptor proteins during cortical axon pathfinding. The 5-year project, starting December 1, 2024, aims to explore how adhesive and instructive signaling pathways...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $481,126 to the University of Chicago to conduct research on the molecular and functional mechanisms of repulsive axon guidance by netrin complexes.

The research aims to develop biochemical strategies to reconstitute netrin-UNC-5 receptor complexes and structurally characterize how these complexes mediate repulsive signaling in neurons, in contrast to the attractive netrin-UNC-40/DCC signaling. This work will leverage genetic studies in C. elegans and in vitro cell culture models to systematically investigate UNC-5 receptor function and signaling. The goal is to address a key mechanistic gap in understanding how netrin-mediated repulsive axon guidance occurs, which is important for proper neural connectivity and function. The award has a performance period from May 2025 through June 2030.

Generated 6/10/25, 4:18 AM