Project Grant R01NS140230

Award Date 12/1/24
Completion Date 11/30/29
Dollars Obligated $548K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Boston, MA 02215, USA
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This Project Grant award of $548,088.00 was made on December 1, 2024 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research by Trustees of Boston University to understand the role of local and long-range cortical circuits in tactile perception and sensory processing. Key activities include:

  1. Obtaining a fine-scale wiring diagram of the primary somatosensory cortex (S1) to understand how stimulus features are bound into integrated representations.

  2. Identifying cell-type-specific circuit motifs in S1 that can differentiate and integrate sensory and motor information.

  3. Mapping the neural dynamics and anatomical connections that support information flow between cortical areas during goal-directed behavior.

The research aims to provide circuit-level insights that can inform and refine computational models of cortical function related to perception and behavior. A sub-award of an unspecified amount was made to Zetta Ai LLC to collaborate on reconstructing serial section electron microscopy datasets of mouse cortex and providing a platform for collaborative analysis.

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