This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $525,436 to the Icahn School of Medicine at Mount Sinai to conduct research on the structural pharmacology of GIRK channel disease mutants. The key objectives are to elucidate the molecular mechanisms underlying the loss of potassium selectivity and G protein-independent...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the non-canonical roles of voltage-gated sodium channels (VGSCs) in neurodevelopmental epilepsy. The $145,642 award to The Trustees of Columbia University will fund a 3-year research project examining the influence of SCN3A gene variants on...
This Project Grant award, totaling $101,668.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to investigate the role of the PANX1 ion channel in cortical development and its potential contribution to the pathogenesis of polymicrogyria, a malformation of the cerebral cortex. Key objectives include...
This Project Grant award of $655,968 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research to unravel the genotype-phenotype connections of three gain-of-function variants of the KCNMA1-encoded BK potassium channel. The goal is to understand how these variants influence distinct molecular gating mechanisms, leading to differential alterations of neuronal...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $242,310 to Oregon Health & Science University to study the role of P/Q-type ion channels in the development of oligodendrocyte lineage cells, which are responsible for producing myelin in the central nervous system. The research aims to understand how disruptions in P/Q-type channels...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $207,387 to the University of Vermont & State Agricultural College to investigate circuit dysfunction in a mouse model of the KCNT1 gene variant, which is linked to intellectual disability and seizure disorders. The research aims to characterize the role of specific...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate electrical signaling in dendritic branches of spiny projection neurons (SPNs) in the basal ganglia. The $457,875 award, effective from July 5, 2024 to June 30, 2026, will enable the University of Connecticut Health Center to test two key...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $460,625 to Yale University to conduct research on the role of the protein Filamin A (FLNA) in the pathogenesis of tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII). The research aims to identify FLNA-interacting proteins that contribute to neuronal...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $195,000 to investigate the cellular mechanisms by which Long QT Syndrome Type 2-associated KCNH2 gene variants disrupt neuronal function. The research will use gene-edited and patient-derived human stem cell-derived neurons to explore the connection between cardiac and neuronal...
This federal Project Grant award, totaling $433,125.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research focused on understanding the function of a small conductance calcium-activated potassium channel, SK2 (KCNN2), in astrocytes and its interaction with adrenergic signaling to regulate astrocyte potassium conductance. The...