This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $211,875.00 to New York University School of Medicine to study the neuroanatomical abnormalities associated with repetitive head impacts in former American football players. The research aims to identify potential biomarkers and supportive features for diagnosing chronic...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Trustees of Boston University is supporting a comprehensive research study on the long-term health consequences of repetitive head impacts (RHI) across the lifespan. The $4,269,339 award, active from June 1, 2025 to May 31, 2027, is expanding the UNITE Brain Bank - the world's largest RHI and chronic traumatic encephalopathy (CTE) brain tissue repository - to investigate how RHI exposure, particularly...
This Cooperative Agreement award under the National Institute of Neurological Disorders and Stroke's (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $1,122,294 to Trustees of Boston University for research to determine the relationship between repetitive head impacts (RHI), traumatic brain injury (TBI), and neurodegenerative diseases such as Alzheimer's disease, Alzheimer's-related dementias, and chronic traumatic encephalopathy. The...
This Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports a $817,484 research project by Trustees of Boston University to characterize the spatial and temporal response to tau protein in chronic traumatic encephalopathy (CTE), a neurodegenerative disease linked to repetitive head injuries. The key objectives are to use cutting-edge approaches like single-nucleus RNA sequencing and spatial transcriptomics on brain tissue samples from the Boston...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $218,896.00 to Trustees of Boston University's Boston University Medical Campus to conduct research on neuroinflammatory alterations in post-traumatic stress disorder (PTSD) and chronic traumatic encephalopathy (CTE). The key objectives are to define microglia-mediated...
This Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports a comprehensive research study titled "Risk and Resilience, Clinical Presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The Diagnose CTE Research Project II". The $6,578,788 award will be used to retain and expand an existing cohort of former football players and controls to examine the clinical features, biomarkers, and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to investigate the relationship between traumatic brain injury (TBI), hematopoietic stem cell dysfunction, chronic neurodegeneration, and Alzheimer's disease (AD). The $102,948 award, active from December 1, 2024 to August 31, 2027, will employ a clinically...
This Project Grant award, valued at $404,100.00, was issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award will support research by The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to investigate the mechanisms of chronic blood-brain barrier dysfunction after traumatic brain injury (TBI). The...
This Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to improve the understanding of traumatic brain injury (TBI) biomechanics. The $559,820 award will enable the University of South Carolina, in collaboration with the Henry M. Jackson Foundation for the Advancement of Military Medicine, to conduct a multimodal study...
This federal Project Grant award, valued at $405,000.00 and granted by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research focused on understanding the effects of traumatic brain injury (TBI) on serotonin (5-HT) neurotransmission. The research aims to identify and characterize TBI-induced alterations in the transcriptional identity of specific...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $843,248 to support innovative research by Trustees of Boston University's Medical Campus. The primary objective is to develop computational algorithms to accurately identify chronic traumatic encephalopathy (CTE) pathology and spatially pinpoint heterogeneous neuropathological features associated with repetitive head impacts (RHI) and clinical symptoms. This research leverages a digital library of over 150,000 whole slide images from multiple brain banks to characterize how RHI and other risk factors impact the regional distribution of neuropathologies, and how these neuropathological changes contribute to clinical outcomes in individuals exposed to RHI. The project period runs from May 7, 2025 through April 30, 2030.