This Project Grant award for $1,386,000.00 was provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The grant supports a comprehensive investigation into the mechanisms underlying the neurotoxic spread of alpha-synuclein protein from the gut to the brain in Parkinson's disease. The research aims to generate new gut-to-brain transmission models in C. elegans to map the spread of alpha-synuclein pathology and...
This Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $984,000 to the University of Chicago to conduct a cross-sectional and longitudinal study on the role of gut microbiota in the development, progression, and prognosis of Parkinson's disease (PD). The 5-year study aims to gain a better understanding of the relationship between...
The federal Cooperative Agreement award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate the relationship between the gut-microbiota-brain axis and the progression of Parkinson's disease. The $514,873 award, with a performance period from August 15, 2024 to June 30, 2029, will enable researchers at the Medical College of Georgia...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to establish the role of alpha-synuclein-mediated membrane permeabilization in the spread of alpha-synuclein aggregates related to Parkinson's disease and related dementias. The $406,260 award to Purdue University will leverage fluorescence lifetime imaging microscopy...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Massachusetts Medical School is focused on understanding how the gut microbiome influences neurodegeneration and protects against Alzheimer's disease. The $647,979 award, effective September 30, 2024 through August 31, 2025, will leverage the C. elegans model system to: Determine how bacterial production of vitamin B12 protects against neurodegeneration pathways. Examine...
This U01 Cooperative Agreement, awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund a multidisciplinary study at Stanford University to investigate the role of altered gut immune response in the pathogenesis of Lewy body diseases, including Parkinson's disease and dementia with Lewy bodies. The $931,408 award, spanning Sept 2024 to June 2029, will employ...
This Project Grant award of $630,905, funded by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program, supports research to explore the role of the gut microbiome-derived metabolite imidazole propionate (IMP) in the progression of Alzheimer's disease and related dementias. The primary objectives are to characterize the relationship between IMP, blood-brain barrier disruption, and Alzheimer's pathology in mouse models, as well as to examine associations between IMP,...
This $484,314 Project Grant was awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074). The funding will support research at Christopher Newport University to investigate the "microbiota-gut-brain axis" and the impact of intestinal barrier dysfunction on aging and neurodegeneration. Key objectives include gaining insights into the cellular and molecular changes associated with an aging gut, how...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $646,104 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the San Diego Biomedical Research Institute, a non-profit research organization. The grant supports research to investigate how neuroinflammation mediated by the interleukin-13 receptor signaling pathway may contribute to the selective loss of dopaminergic neurons in Parkinson's disease. The...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $224,807 to the University of California, Irvine (UCI) to conduct research on identifying and engineering microbial enzymes that can modulate peptidoglycan (PG) metabolite levels in the gut microbiome. The goals are to discover highly active, secreted, and stable PG-degrading enzymes (Aim 1) and develop genetic tools...