This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate the role of the gut microbiome in the initiation and spread of alpha-synuclein aggregation, a key factor in the development of Parkinson's disease. The $501,059 award, with a period of performance from Sep 1, 2024 to Aug 31, 2029, will fund research conducted by the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to establish the role of alpha-synuclein-mediated membrane permeabilization in the spread of alpha-synuclein aggregates related to Parkinson's disease and related dementias. The $406,260 award to Purdue University will leverage fluorescence lifetime imaging microscopy...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to identify changes in synaptic vesicle-binding of alpha-synuclein as an early biomarker for Parkinson's disease (PD) and Alzheimer's disease related dementias (ADRD). The $793,535 award, with a project period from December 1, 2024 to November 30, 2029, will fund studies...
This $2,192,716 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to understand the role of serine-129 phosphorylation in the aggregation and spreading of α-synuclein pathology associated with Parkinson's disease, dementia with Lewy bodies, and related synucleinopathies. The project leverages novel serine-129 phospho-deficient and...
This federal Project Grant award of $2,208,982 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of the interleukin-13 receptor in Parkinson's disease. The research aims to determine the molecular and cellular mechanisms by which activation of the interleukin-13 receptor alpha 1 (IL-13RA1) can affect the survival of dopaminergic...
This federal Project Grant award, identified as F31NS137765, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $173,140 grant, awarded on Sep 30, 2024, supports research to investigate the role of neural activity in the degeneration of midbrain dopamine neurons, which is a key pathological process in Parkinson's disease. The project will utilize...
This $1,585,446 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop a "nano scavenger" diagnostic and therapeutic agent for Parkinson's disease (PD). The research, conducted by Baylor College of Medicine, aims to validate the preclinical potential of a liposome-based agent that binds to oligomeric alpha-synuclein in...
This Project Grant award of $616,200.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, will support research to explore the role of neuromelanin accumulation in dopamine neurons and its impact on Parkinson's disease. The primary awardee, the Oklahoma Medical Research Foundation (OMRF), will leverage expertise across three established labs to investigate the...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $646,104 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the San Diego Biomedical Research Institute, a non-profit research organization. The grant supports research to investigate how neuroinflammation mediated by the interleukin-13 receptor signaling pathway may contribute to the selective loss of dopaminergic neurons in Parkinson's disease. The...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support a systematic investigation of disease-associated, regulatory variation and its impact on the risk and progression of Parkinson's disease (PD). The $635,430 award will fund research to: 1) Define chromatin and transcriptional signatures in PD-vulnerable dopaminergic neurons over...