Project Grant R01NS138748
- This $488,232 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is funding research by The Washington University to explore the mechanisms by which astrocytes, a type of glial cell, support the metabolic needs of neighboring neurons in the brain. The 5-year project aims to investigate the regulation of intracellular and...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $361,975 to support research focused on developing chemical strategies for imaging and manipulating astrocytes in the brain. The project aims to expand the capabilities of an astrocyte-targeting chemical tag to enable direct visualization and modulation of astrocyte...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $168,455 to New York University School of Medicine to investigate region-specific factors in reactive astrocytes during neuroinflammation. The research project aims to explore the heterogeneous responses of astrocytes, the most abundant brain glial cells, to inflammation, focusing on...
- This $234,750 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research at the University of Missouri System into altered arterial smooth muscle and its role in cerebrovascular dysfunction during aging. The research aims to investigate how changes in cell adhesion molecules like integrin A5B1 and N-cadherin contribute to excessive...
- This $632,776 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) aims to fundamentally advance the understanding of astrocyte physiology. The grant supports research at Baylor College of Medicine to use novel genetically encoded voltage indicators (GEVIs) to measure astrocyte membrane potential and local neural activity in the mouse visual...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support metabolomic research related to intracerebral hemorrhage (ICH) recovery. The $669,092 award, with a period of performance from May 2025 to April 2029, will leverage samples and data from two large genetic epidemiology studies of ICH to assess 5,400 metabolites and identify...
- This federal Project Grant award of $446,126 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new bioassay to study astrocyte borders and profile their functional states in the context of diverse non-neural cell populations. The key objectives are to optimize the bioassay by combining injectable cellulose-based hydrogels with viral vectors to...
- This federal Project Grant award of $629,796 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to track, quantify, and localize key metabolic pathways that regulate brain growth during development. Specifically, the project will investigate two critical metabolic switches in the developing mouse brain: (1) a shift from glycolytic to...
- This Project Grant award of $192,500 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to define the contribution of endothelial cell sphingolipid metabolism to outcomes of acute ischemic stroke in mice. The award, effective December 1, 2024, will enable the University of Utah to leverage innovative murine models and novel ceramide biosynthesis...
- This Project Grant award, totaling $429,000.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award will fund research at Oregon Health & Science University (OHSU) to investigate the fundamental interactions between astrocytes and oligodendrocytes, two major types of glial cells in the central nervous system, and how these...
This $622,881 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research at the University of Missouri System into the metabolic reprogramming of reactive astrocytes and brain repair after focal cerebral ischemia. The research aims to study the mechanisms by which astrocytes undergo metabolic adaptations to support their proliferation and activation in response to ischemic brain injury, with the goal of providing insights that could inform new therapeutic approaches. Key areas of focus include investigating the role of the enzyme nicotinamide phosphoribosyltransferase (NAMPT) in regulating astrocyte metabolism and the effects of NAMPT disruption on brain damage, neuronal death, and motor function deficits. This 5-year project grant, awarded in August 2025, will support the University of Missouri System's specialized neuroscience research capabilities to advance understanding of the metabolic processes underlying astrocyte reactivity and brain repair mechanisms following ischemic stroke.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $622.9k | 8/5/25 |