This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $121,554.00 to the University of California, San Diego (UCSD) to investigate the role of the KIF5A gene in amyotrophic lateral sclerosis (ALS). The research aims to: (1) examine the impact of ALS-related KIF5A mutations on the proteotoxic pathway, (2) explore the interactions...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $340,258 to Emory University to conduct research on assessing the contribution of cortical hyperactivity to amyotrophic lateral sclerosis (ALS) phenotypes using a human-derived motor system model. The research aims to elucidate the relationship between cortical hyperexcitability, a...
This $1,938,189 Project Grant award was made by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to Emory University in Atlanta, Georgia. The project aims to expand understanding of the role of chimeric dipeptide repeat proteins (CDPRs) in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) caused by the C9ORF72 gene mutation. Key objectives include: 1) Identifying the complexity, extent, and mechanism of CDPR pathology in...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $558,182 to The Washington University in St. Louis to conduct research on identifying mechanisms of neurofilament regulation and turnover in amyotrophic lateral sclerosis (ALS). The key objectives of this research project are to: 1) Compare neurofilament isoforms...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $645,391 to The Trustees of Columbia University in the City of New York to investigate the effects of re-expressing embryonic motor neuron selector transcription factors on amyotrophic lateral sclerosis (ALS) pathology. The project aims to test the hypothesis that changes...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $427,625 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853) to The Washington University in St. Louis. The research project aims to develop a novel cellular model for investigating the mechanisms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) using directly converted neurons derived from patient...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $460,625 to the University of Massachusetts Medical School to develop mutant-specific antisense oligonucleotides (ASOs) as potential therapeutics for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The key objectives are to: 1) Design and evaluate...
This $251,250 federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the connection between dysfunction of neuroimmune-related processes and amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) disorders. The research will use a mouse model of mutant TDP-43, a key pathological protein...
This federal Project Grant award of $2,307,075.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research efforts by The Leland Stanford Junior University (Stanford University) to explore novel mechanisms and therapeutic strategies for neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Parkinson's...