This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research to investigate the regulation of invadosome-mediated peripheral axon guidance by ErbB signaling. The $434,769 award, made on June 27, 2025, will support the University of Wisconsin-Madison's efforts to better understand the molecular mechanisms that control axon guidance and growth cone protrusions across three-dimensional tissues and basement membranes. The research aims to elucidate the specific receptors, ligands, and signaling pathways that promote invadosome formation and maturation, and their role in enabling peripheral axons to exit the spinal cord. This work is expected to advance scientific understanding of neuronal development and guidance, with potential implications for addressing neurological disorders.