This federal Project Grant award of $897,250 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research focused on understanding the role of biomolecular condensates, such as ribonucleoprotein (RNP) granules, in governing RNA metabolism and their relationship to neurological diseases. The 8-year research program, led by St. Jude Children's Research Hospital...
This Project Grant award of $1,002,148 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the molecular and structural mechanisms regulating autophagy, a key cellular process, in neurons. The award recipient, the University of California, Berkeley, will conduct a range of studies using advanced techniques like cryo-EM, structural modeling,...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $390,000.00 in funding to Georgia State University Research Foundation Inc. to support research on protein ubiquitination and deubiquitination in neurological disorders. The research aims to elucidate the role of protein ubiquitination and deubiquitination processes...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $467,599.00 to Syracuse University to conduct research on the architecture and function of ubiquitin-binding biomolecular condensates and their role in protein quality control. The 5-year project aims to achieve a mechanistic understanding of how ubiquitin-binding shuttle proteins, such as Ubiquilins and Rad23s, regulate the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $460,625 to the University of Massachusetts Medical School to investigate the role of the deubiquitylation pathway in regulating TDP-43 pathology associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The 2-year project will use mouse...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the role of the GPNMB gene in the pathogenesis of Parkinson's disease, Lewy body dementia, and related synucleinopathies. The $655,329 award to the Albert Einstein College of Medicine aims to identify causal genetic variants that regulate GPNMB expression...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research at the University of California, San Diego (UCSD) to explore the role of liquid-liquid phase separation (LLPS) in regulating neuronal heterochromatin. The $941,337 award, effective August 1, 2024 through May 31, 2029, will support experiments using novel in vivo genetic...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) program, provides $913,225.00 in funding to St. Jude Children's Research Hospital Inc. to conduct research on the proteogenomics of splicing proteinopathies in neurodegeneration, with a focus on Alzheimer's disease (AD). The key objectives of this 5-year project are to systematically characterize the role of U1 small nuclear ribonucleoprotein (U1 SNRNP) proteinopathy and associated...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $2,307,075 to The Leland Stanford Junior University (Stanford University) to support research aimed at defining novel mechanisms of neurodegenerative diseases and developing new therapeutic strategies. The key activities include: Using a combination of yeast and human genetics to...
This federal Project Grant award of $694,134 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to develop an approach to efficiently engineer autologous hematopoietic stem cells (HSCs) with a CSF1R inhibitor resistant variant and conditional galactosylceramidase (GALC) overexpression. This therapeutic approach seeks to enhance the...