Project Grant R01NS138043
- This federal Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $226,608.00 to support research on dissecting the mechanisms of dopamine transmission and its roles in reward-related behaviors. The research will investigate how dopamine signaling occurs at the subcellular level and the implications for neuropsychiatric diseases and substance abuse disorders. The grant was awarded to the University of Colorado-Denver on...
- This $616,200 Project Grant was awarded on February 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to explore the influence of neuromelanin, a dark pigment, on dopaminergic neurons in Parkinson's disease. The project aims to develop a novel mouse model that accumulates neuromelanin in dopamine neurons to study the resulting...
- This federal Project Grant award of $774,632 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award supports research to understand how changes in dopamine signaling impact neural circuits and contribute to symptoms like impaired cognition and perception in dopamine-associated neuropsychiatric diseases. The key objectives are to use in vivo imaging to determine how selectively activating dopamine neurons in the...
- This Project Grant award of $422,125 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research to investigate the fundamental roles of the DNAJC12 protein in dopamine production and brain function. The research aims to specifically ablate DNAJC12 in dopaminergic neurons in order to ascertain the effects of this gene dysfunction on dopamine synthesis,...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $123,588 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Rutgers, The State University in New Jersey. This 2-year grant, awarded on September 1, 2025, will support research to explore the relationship between altered motor behavior and dopamine transients in the dorsolateral striatum following spinal cord injury. The research aims to establish...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $529,878 to Boston Children's Hospital from December 1, 2024 to November 30, 2029. The project aims to investigate the molecular mechanisms underlying the desensitization of dopamine receptors that occurs after goal-directed behaviors, such as mating in Drosophila. This...
- This federal Project Grant award of $613,786.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is supporting research to elucidate the molecular, cellular, and physiological consequences of D1 dopamine receptor (D1DR) signaling from both the plasma membrane and Golgi compartments in primary medium spiny neurons. The research aims to advance understanding of the role of compartmentalized D1DR signaling in the neurobiology...
- This federal Project Grant award of $220,260.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The purpose of the grant is to investigate the role of the RNA-binding protein ELAVL3 in regulating glutamate and dopamine receptor signaling in the striatal neurons of the brain, with the goal of understanding the molecular mechanisms underlying striatal...
- This federal Project Grant award of $140,690 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to investigate the relationship between gamma oscillations in the motor network and dyskinesia (excessive movement) in Parkinson's disease patients. The goals are to use chronically implanted neurostimulators and wearable sensors...
- This federal Project Grant award for $613,017.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to examine the interdependent neural circuit mechanisms underlying the timing of dopamine reward omission signals and striatal dynamics in mice. The project, conducted by the University of California, Los Angeles (UCLA), aims to elucidate how dopamine and striatal timing processes interact to enable...
This federal Project Grant award of $501,125.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to determine the mechanisms of dopamine transmission in the brain and how it regulates motor function and learning. The research aims to understand how different dopamine signals mediate transmission and impact aspects of motor activity and learning, which has implications for understanding and treating neurological disorders such as Parkinson's disease. The project will use novel approaches to measure local receptor-mediated dopamine signals and bulk dopamine spillover to test the hypothesis that these different dopamine signals can be independently regulated and drive distinct behavioral functions. This 5-year award to the University of Colorado-Denver will advance fundamental knowledge of dopamine system dynamics and their role in motor control.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $501.1k | 7/31/25 |