Project Grant R01NS137950

Award Date 7/9/24
Completion Date 6/30/29
Dollars Obligated $416K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94143, USA
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The key objectives are to: 1) define the cortical neuron laminar structure and excitatory-inhibitory transcriptional programs within glioma-infiltrated cortex; 2) determine the functional consequences of glioma infiltration on information processing in sensory regions; and 3) identify the functional consequences of glioma infiltration on information processing in higher-order speech and motor regions. This research aims to advance the understanding of information loss in low-grade glioma and identify potential target mechanisms for future clinical trials focused on restoring excitatory-inhibitory balance. The award period runs from July 9, 2024 to June 30, 2029.

Additionally, the grant includes a sub-award to the University of Michigan to leverage their expertise in systems neuroscience and neural distinctiveness to support the data analysis, manuscript preparation, and dissemination of relevant findings.

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