The National Institutes of Health (NIH) Office of the Director awarded a 5-year, $498,444 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Administrators of Tulane Educational Fund, doing business as Tulane University. The grant supports research to investigate the effects of HIV-associated extracellular vesicles on mitochondrial dysfunction and blood-brain barrier disruption in brain microvessels. The goal is to explore how HIV-free extracellular vesicles...
This federal Project Grant award, worth $382,072, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to investigate the epigenetic mechanisms underlying HIV-associated neurocognitive disorders (HAND), which remain a significant complication of HIV infection despite antiretroviral therapy. The research will focus on characterizing the...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $843,177 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of California, Los Angeles (UCLA) to evaluate the efficacy of broadly neutralizing antibodies (BNABs) encapsulated in nanotechnology-based "nanocapsules" for targeting central nervous system (CNS) HIV infection in infants. The research aims to improve the delivery of BNABs to...
This Project Grant award for $665,171.00, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to improve outcomes for individuals with HIV-associated opportunistic infections like cryptococcal and TB meningitis. The key objectives are to: 1) define CSF drug concentrations or AUC/MIC ratios that predict fungal clearance, 2) determine the relationship between...
The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, awarded a $2,272,234 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Rochester. The goal of this 5-year award is to determine the role of monocyte delta-like 4 (DLL4) in cerebral small vessel disease and its impact on cognition in people with HIV. The research aims to investigate how monocyte...
This $1,454,724 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to understand the mechanisms involved in HIV-1 latency in the central nervous system (CNS). The primary objectives are to identify key factors, pathways, and regulators that determine the establishment, maintenance, and reactivation of latent HIV-1 virus in brain myeloid cell lineages, such as microglia and macrophages. The research will...
The National Institute on Aging (NIA), through its Aging Research program (CFDA 93.866), has awarded a $534,644.00 Project Grant to Temple University - Of The Commonwealth System Of Higher Education. The grant aims to characterize how the HIV-1 virus decreases neuronal clearance, leading to the progression of HIV-associated neurocognitive disorders like motor dysfunction. Key research activities include determining the post-translational regulation of the SNAPIN protein and its impact on...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $652,375 to the University of Nebraska Medical Center to conduct research on the molecular causes of neurological disorders in people living with HIV infection (PLWH). The key objectives are to: 1) Define the relationship between the glycolysis byproduct methylglyoxal (MG),...
The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), has awarded a $1,372,480 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Board of Regents of the University of Nebraska's University of Nebraska Medical Center (UNMC) division. The 5-year grant, effective April 15, 2025 through January 31, 2030, will fund research to elucidate the molecular mechanisms by which the interplay of HIV transactivator of transcription...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of the CCL2/CCR2 signaling pathway in modulating HIV-associated ischemic stroke severity and recovery. The $422,125 award, effective from September 18, 2024 to August 31, 2026, will be conducted by the University of Miami. The research aims to...