Project Grant R01NS136464
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $390,000.00 in funding to Georgia State University Research Foundation Inc. to support research on protein ubiquitination and deubiquitination in neurological disorders. The research aims to elucidate the role of protein ubiquitination and deubiquitination processes...
- Emory University received a $430,375 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to elucidate the subcellular dynamics of ubiquitination, a key biological process regulating synaptic function and neuronal health, using advanced single-molecule imaging techniques. The research aims to uncover new mechanisms by...
- This Project Grant award of $460,625 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting research to investigate the roles of the deubiquitylation pathway in TDP-43 pathology associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research is being conducted by the University of Massachusetts Medical School (UMMS) and...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $427,625 to the University of Wisconsin System for research to systematically identify differentially ubiquitinated proteins, potentially UBE3A substrates, in UBE3A model mice in different cell types (excitatory and inhibitory neurons) at different developmental stages. The...
- This federal Project Grant award, valued at $147,486, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The purpose of this award is to investigate the function of a ciliary protein in neural development, with a focus on uncovering novel molecular mechanisms involved in synapse formation that may be relevant to neurological disorders. Using C. elegans as...
- This $2,503,949 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rockefeller University aimed at discovering therapeutic targets for neurological diseases. The project utilizes new techniques and concepts to study the fundamental mechanisms of brain disorders, focusing on how differences in cell-specific RNA regulation contribute to...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $2,723,954.00 to the University of Alabama at Birmingham (UAB) from June 1, 2025 to May 31, 2027. The grant supports research focused on understanding the effects of 14-3-3θ protein phosphorylation on vesicular transport and alpha-synuclein aggregation, which are key mechanisms...
- This $1,002,148 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research on the role of autophagy, a cellular process for clearing damaged organelles and inclusions, in neurodegeneration. The research aims to determine how levels of the lipid phosphatidylinositol 3-phosphate (PI(3)P) regulate autophagy in neurons, including...
- This federal Project Grant award of $458,189 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research focused on understanding how specific membrane-remodeling factors regulate oligodendrocyte membrane dynamics and myelination in the central nervous system. The research aims to elucidate the mechanisms by which these factors shape...
- This $512,423 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at the University of Utah to investigate the role of the IGF2BP family of RNA binding proteins in brain development and their relationship to neurodevelopmental disorders. The research aims to elucidate how the fly orthologue IMP regulates the mRNA target...
This federal Project Grant award of $403,997 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research by the Georgia State University Research Foundation Inc. to investigate the role of protein ubiquitination and deubiquitination in neurological disorders. The research aims to: 1) determine if the E3 ubiquitin ligase RNF216 regulates the deubiquitinase OTUD4 in a destabilizing manner, and if a mutation in OTUD4 associated with Gordon Holmes Syndrome affects its stability; 2) investigate whether OTUD4 can directly deubiquitinate and affect the stability and catalytic activity of RNF216; and 3) explore the broader mechanisms by which protein ubiquitination and deubiquitination contribute to neurological function and disease. This 4-year project starting on September 1, 2025 seeks to advance the understanding of ubiquitin-mediated processes in the nervous system and their links to neurodegenerative disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $404.0k | 8/1/25 |