Project Grant R01NS136423
Award Date
12/1/24
Completion Date
11/30/29
Dollars Obligated
$794K
Federal Agency
National Institute of Neurological Disorders and Stroke
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
New York, NY 10065, USA
Similar Awards
This federal Project Grant award in the amount of $684,451 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders supports a comprehensive research effort to advance understanding and treatment of Parkinson's disease. The project aims to: Identify Parkinson's disease progression subtypes through integrative analysis of longitudinal clinical, transcriptomic, and neuroimaging data...
The Research Foundation for the State University of New York (RF SUNY) received a $158,379 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The funding will support research to understand how the protein alpha-synuclein (α-syn) contributes to mitochondrial dysfunction in Parkinson's disease (PD). The project aims to isolate the...
This $655,329 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research to determine the role of the GPNMB gene in the pathogenesis of Parkinson's disease, Lewy body dementia, and related synucleinopathies. The research team at Albert Einstein College of Medicine will use CRISPR/Cas9 genome editing in human pluripotent...
This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate the role of synaptic organizers in Parkinson's disease pathology and potential therapeutic interventions. The total funding amount is $669,115, awarded on September 1, 2024 with a project period ending on August 31, 2029. The research project, led by Texas A&M...
This Project Grant award of $414,191 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research by Drexel University investigating the relationship between structural variations in alpha-synuclein (α-syn) protein fibrils and the development of distinct neurodegenerative synucleinopathies such as Lewy body dementia, Parkinson's disease, and multiple system atrophy....
This $2,768,769 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the influence of the GBA1 gene on the regulation, trafficking, and maturation of key lysosomal proteins involved in the metabolism of alpha-synuclein. The research will use wildtype and isogenic iPSC-derived neurons to examine how GBA1 mutations affect alpha-synuclein degradation, neuronal release, and the accumulation of alpha-synuclein species found in Lewy...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to establish the role of alpha-synuclein-mediated membrane permeabilization in the spread of alpha-synuclein aggregates related to Parkinson's disease and related dementias. The $406,260 award to Purdue University will leverage fluorescence lifetime imaging microscopy...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA Program 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, will provide $2,280,379 to the Regents of the University of Michigan to develop novel nanobody-based agents that can target pathogenic alpha-synuclein to block its cell-to-cell transmission. The grant aims to characterize these nanobody-based agents and assess their in vitro and in...
This federal Project Grant award of $231,255 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to identify the tissue source and functional properties of plasma-derived alpha-synuclein strains associated with Parkinson's disease (PD). The five-year grant, awarded to the University of Pennsylvania, aims to use extracellular vesicles to uncover the...
This $2,192,716 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to understand the role of serine-129 phosphorylation in the aggregation and spreading of α-synuclein pathology associated with Parkinson's disease, dementia with Lewy bodies, and related synucleinopathies. The project leverages novel serine-129 phospho-deficient and...