This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $682,493 to the Albert Einstein College of Medicine to elucidate the role of aberrant histone acetylation in the pathogenesis of Parkinson's disease and related synucleinopathies. The research involves utilizing a human pluripotent stem cell-based discovery platform...
This three-year, $3.4 million Project Grant from the National Institute on Aging will support research into the combinatorial effects of post-translational modifications on alpha-synuclein structure, function, and aggregation. The Trustees of the University of Pennsylvania will investigate how multiple simultaneous modifications to alpha-synuclein impact its interactions with lipid bilayers, self-association kinetics, aggregate structural features, internalization by neurons, and seeded...
This $2,192,716 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to understand the role of serine-129 phosphorylation in the aggregation and spreading of α-synuclein pathology associated with Parkinson's disease, dementia with Lewy bodies, and related synucleinopathies. The project leverages novel serine-129 phospho-deficient and...
This $1,009,212 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research into a novel gene therapy approach to reduce neurotoxicity in Parkinson's disease. The primary awardee, Van Andel Research Institute (VAI), will conduct pharmacodynamic, pharmacokinetic, and in vivo efficacy studies to develop a gene therapy that aims to enhance the...
This Project Grant award of $414,191 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research by Drexel University investigating the relationship between structural variations in alpha-synuclein (α-syn) protein fibrils and the development of distinct neurodegenerative synucleinopathies such as Lewy body dementia, Parkinson's disease, and multiple system atrophy....
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to identify changes in synaptic vesicle-binding of alpha-synuclein as an early biomarker for Parkinson's disease (PD) and Alzheimer's disease related dementias (ADRD). The $793,535 award, with a project period from December 1, 2024 to November 30, 2029, will fund studies...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support a systematic investigation of disease-associated, regulatory variation and its impact on the risk and progression of Parkinson's disease (PD). The $635,430 award will fund research to: 1) Define chromatin and transcriptional signatures in PD-vulnerable dopaminergic neurons over...
This Project Grant award of $628,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate how Alzheimer's disease (AD) pathogenesis interferes with synaptic autophagy and whether targeting synaptic autophagy can be neuroprotective in an AD mouse model. The research will utilize primary hippocampal cell cultures and mouse models to determine which steps in the autophagic processing of synaptic proteins are disrupted by AD, and evaluate if overexpressing the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,086,563 to The Trustees of the University of Pennsylvania to conduct research on the regulation of autophagy and lysosomal pathways in astrocytes and neurons in response to proteotoxic stress associated with alpha-synucleinopathies. The goal is to define the cell-type-specific differences in how quality control pathways are managed in neurons versus astrocytes, which may explain the increased...
This Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to understand the role of 14-3-3θ phosphorylation in regulating alpha-synuclein aggregation and transport, which are key factors in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The $2,723,954 award to the University of Alabama at Birmingham will fund a...