This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $858,471 to The Trustees of the University of Pennsylvania to investigate the role of N-terminal acetylation in alpha-synuclein stability, function, and therapeutic targeting for Parkinson's disease and related dementias. The key objectives are to: 1) identify the molecular...
This federal Project Grant award of $7,704,350.00 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to The Trustees of the University of Pennsylvania to fund a 5-year research center to investigate "Mechanisms Underlying Heterogeneity of Cognitive Outcomes in Synucleinopathy." The research center will conduct four synergistic projects to understand why the same alpha-synuclein pathology can lead to dramatically different cognitive trajectories in patients...
This federal Project Grant award of $1,086,563 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to define the regulation of lysosome-mediated pathways (autophagy and endolysosomal) within and between astrocytes and neurons in response to proteotoxic stress elicited by fibrillar forms of α-synuclein. The research aims to elucidate cell-type-specific responses and vulnerabilities in neurodegenerative diseases such as Parkinson's, Alzheimer's, Huntington's,...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on investigating the origin and pathogenic properties of alpha-synuclein strains found in the plasma of individuals with Parkinson's disease (PD). The $231,255 award, effective July 15, 2024 through June 30, 2029, will support the following key research activities:...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will provide $414,191 to Drexel University from August 1, 2024 to July 31, 2026. The research aims to investigate how alpha-synuclein (α-syn) protein fibril conformations influence the emergence of distinct pathologies in synucleinopathies, including Lewy body dementia,...
This $2,192,716 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to understand the role of serine-129 phosphorylation in the aggregation and spreading of α-synuclein pathology associated with Parkinson's disease, dementia with Lewy bodies, and related synucleinopathies. The project leverages novel serine-129 phospho-deficient and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $223,750 to Brigham & Women's Hospital Inc. to conduct research on distinguishing normal and abnormal forms of the protein alpha-synuclein (α-synuclein) and their impact on synaptic transmission. The research aims to elucidate the differences in the biological properties of normal and pathological phosphorylation of α-synuclein at serine 129 (pS129) in order to refine pS129 as a marker...
The National Institute on Aging (NIA) awarded a $717,491 Project Grant under its Aging Research program (CFDA 93.866) to New York University (NYU) School of Medicine to develop single domain antibodies (sdAbs) that can detect and clear alpha-synuclein (αSyn) in animal models of synucleinopathies. The project aims to evaluate the in vivo imaging potential, clearance mechanisms, and therapeutic efficacy of these sdAbs targeting αSyn, a key protein involved in neurodegenerative diseases like Lewy...
This $406,260 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program will support research to investigate the spread of alpha-synuclein protein aggregates, which is a key mechanism believed to underlie the onset and progression of Parkinson's disease and related dementias. The research aims to characterize the aggregation states of...
The National Institute on Aging (NIA) awarded a $2,069,215 Project Grant (CFDA 93.866) to Case Western Reserve University (CWRU) to investigate the role of the beta-arrestin2-LMBRD2 cascade in the pathogenesis of alpha-synuclein, a key protein involved in Lewy body diseases like Parkinson's disease and dementia with Lewy bodies. The research aims to elucidate the mechanisms governing the internalization and transmission of pathological alpha-synuclein, which is critical for understanding disease...
This three-year, $3.4 million Project Grant from the National Institute on Aging will support research into the combinatorial effects of post-translational modifications on alpha-synuclein structure, function, and aggregation. The Trustees of the University of Pennsylvania will investigate how multiple simultaneous modifications to alpha-synuclein impact its interactions with lipid bilayers, self-association kinetics, aggregate structural features, internalization by neurons, and seeded aggregation of endogenous alpha-synuclein. Using a novel semi-synthesis strategy, the researchers will produce site-specifically modified alpha-synuclein containing single and multiple modifications associated with Parkinson's disease, Lewy body dementia, and multiple system atrophy. This work aims to provide insight into potential "strain" differences between synucleinopathies and guide development of targeted therapies. The funding falls under the Aging Research program (CFDA 93.866), which supports biomedical research on aging and age-related diseases.