Project Grant R01NS132773

Award Date 9/1/24
Completion Date 7/31/29
Dollars Obligated $391K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Louisville, KY 40202, USA
Similar Awards
This federal Project Grant award of $462,296.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the anatomical plasticity and functional impact of long-ascending propriospinal neurons (LAPNs) following spinal cord injury in rats. The research aims to characterize LAPN dendritic and axonal changes before and after various spinal cord injury...
This $1,006,322 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research to develop a regeneration classifier that can predict the regenerative potential of diverse neuronal types after spinal cord injury. The research, conducted by the University of California, San Diego, will expand on the team's prior success in using patch-based...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $469,898.00 to Yale University to conduct research on mechanisms that support raphespinal tract plasticity and regeneration after spinal cord injury. The project aims to use anatomy, spatial transcriptomics, and intersectional in vivo chemogenetics to define the capacity...
This $458,154 Project Grant was awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant supports research by Microcures Inc. to develop a nanoparticle-encapsulated small interfering RNA (siRNA) therapy targeting the Fidgetin-like 2 (FL2) protein. This novel therapy aims to promote tissue repair and functional recovery after spinal cord...
This $424,875.00 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund a comprehensive study of gene transcription patterns in diverse classes of neurons that connect the brain to the spinal cord after spinal cord injury in a mouse model. The research team at Marquette University will use single-cell sequencing technologies to profile...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $151,559 to Rensselaer Polytechnic Institute (RPI) to develop innovative magnetically responsive drug delivery electrospun fibers to improve regeneration after spinal cord injury (SCI). The project aims to fabricate magnetic, growth factor-loaded coaxial electrospun...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research to develop a polymer-based drug delivery system to promote spinal cord repair. The $184,837 award to The Ohio State University will support experiments to optimize conditions for fabricating drug-loaded microspheres, characterize their release profiles, and evaluate...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $437,250 to the University of California, San Diego (UCSD) to conduct in vivo screening of combination gene therapies for axonal regeneration after spinal cord injury. The project aims to efficiently identify new combinations of genetic targets that can enhance both the...
The University of Washington received a federal Project Grant award of $506,696.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant funds research to examine and evaluate critical microvascular blood flow parameters that can reduce cervical spinal tissue loss and improve functional recovery after cervical spinal cord injury (SCI) in a rodent model. The...
The National Institutes of Health's National Institute of Neurological Disorders and Stroke awarded The Ohio State University a $119,018 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders program. This grant will support research into strategies to interrogate and enhance myelin remodeling in distal tissue after spinal cord injury. The goal of the NINDS program is to fund basic and applied research exploring the brain, nervous system structure...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research on promoting axon regeneration and functional recovery after spinal cord injury. The $391,250 award to the University of Louisville will fund a 5-year study with the following key objectives: 1) Evaluating controlled PTEN deletion to overcome barriers to corticospinal tract regeneration without adverse effects; 2) Determining the role of the corticospinal tract in PTEN-deletion induced functional recovery; and 3) Examining the impact of chondroitin sulfate proteoglycans on the growth of PTEN-deleted axons. This innovative research aims to develop effective therapeutic strategies for spinal cord injury by optimizing the timing of PTEN regulation and investigating the underlying mechanisms of axon regeneration and functional restoration.

Generated 6/24/25, 5:09 AM