Repeated assessment of survivors in ICH (reassess ICH)
Active Project Grant Awarded Last action
- Award ID
- R01NS120557
- Recipient
-
The Johns Hopkins University UEI FTMTDMBR29C7
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $9,742,868
Award facts
- Assistance listing
- 93.866 Aging Research
- Completion date 80% complete
- Originally
- Place of performance
- Maryland, USA
Award details come from USAspending.gov.
Description
- Abstract
- Purpose: the repeated assessment of survivors in ICH study will conduct long-term cognitive, functional, and neuropsychiatric performance assessments to determine if evacuation of spontaneous intracerebral hemorrhage (ICH) reduces the risk of later cognitive decline in the ageing brain. This study will compare rates of cognitive decline under two treatment strategies for intracerebral hemorrhage: the use of minimally invasive surgery with two similar techniques as performed in the recently completed mistie III and enrich trials, and the current standard of care using data from both controls in mistie III and enrich and comparative data from the ethnic/racial variations of ICH (erich) study (u-01-NS067963) extended into the erich- longitudinal study (R01-NS093870) which followed over 900 of the cases with serial cognitive examinations. Rationale: intracerebral hemorrhage has the highest disability rate among stroke survivors. ICH survivors are at particularly high risk for progressive cognitive impairment which is strongly associated with greater hematoma volume, but also with cerebral amyloid angiopathy. Compared with standard of care, minimally invasive surgery with effective hematoma volume reduction may improve long-term functional outcomes while also reducing mortality. As such, reducing hematoma volume after ICH may reduce the risk of post ICH cognitive decline. Design: reassess ICH is a longitudinal structured serial telephone interview follow-up plus one-time in- person visit of an anticipated 359 ICH survivors enrolled in mistie III (2013-2017) or enrich (2018-2022). Cognitive and functional outcome data will be compared with up to 900 patients enrolled in erich-l, to determine if surgical ICH reduction leads to reduced risk of progressive cognitive decline. Primary aim 1: to determine if surgical clot reduction after ICH reduces the risk of progressive cognitive decline. Hypothesis: the final residual volume of ICH will correlate with risk of cognitive decline after controlling for age, SEX, initial volume of ICH, leukoaraiosis, apoe genotype, and hypertension treatment among operated and non-operated survivors of mistie III/enrich and survivors of erich, and effective clot reduction (
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $211,982 | |
| Amendment | $579,933 | |
| Amendment | $579,933 | |
| Amendment | $23,342 | |
| Amendment | $161,903 | |
| Amendment | $161,903 | |
| Amendment | $210,075 | |
| Amendment | $1,457,131 | |
| Amendment | $1,457,131 | |
| Amendment | $1,457,131 | |
| Amendment | $224,137 | |
| Amendment | $224,137 | |
| Amendment | $224,137 | |
| Amendment | $224,137 | |
| Amendment | $224,137 | |
| Amendment | $224,137 | |
| Amendment | $979,826 | |
| Amendment | $137,930 | |
| Original award | $979,826 |
Show all 21
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Cincinnati Univ Of | $232,611 | |
| Yale Univ | $483,986 | |
| Wake Forest University Health Sciences | $585,226 | |
| Icahn School Of Medicine At Mount Sinai | $39,691 | |
| Cincinnati Univ Of | $1,089,857 | |
| Duke University | $25,000 | |
| Yale Univ | $57,079 | |
| Trustees Of Indiana University | $51,381 | |
| Rush University Medical Center | $37,203 | |
| Emory University | $36,935 | |
| University Of Pittsburgh - Of The Commonwealth System Of Higher Education | $69,947 | |
| Yale Univ | $191,199 |
Show all 12
Quick answers
Who received award R01NS120557?
R01NS120557 was awarded to The Johns Hopkins University by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on January 1, 2022.
How much is award R01NS120557 worth?
$9,742,868 has been obligated on R01NS120557.
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