Project Grant R01NS033981

This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $415,250 to Ohio University to develop helical peptide antagonists of the growth hormone receptor (GHR). The project aims to synthesize and test two classes of structured derivatives of a previously identified GHR antagonist peptide, S1H, to determine their ability to inhibit growth hormone signaling in vitro and in vivo. The structured peptides will be evaluated through binding...

The National Institute on Aging, part of the Department of Health and Human Services, awarded $2,459,487 under its Aging Research grant program (CFDA 93.866) to Seattle Children's Hospital on May 15, 2022 for a project concluding on April 30, 2025. The award will support research using in vivo multi-photon imaging techniques to investigate age-related impairment of venous drainage in deep gray and white matter regions of the mouse brain. Specifically, the researchers will test hypotheses about...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $153,696 to The Leland Stanford Junior University to investigate the developmental origins and functional characteristics of myeloid-biased hematopoietic stem cells (HSCs) present in the fetal liver. The research aims to elucidate how these myeloid-biased HSCs arise during prenatal development and contribute to age-associated changes in hematopoiesis. The study will employ advanced techniques...

The National Institute on Aging awarded a $753,728 Project Grant (CFDA 93.866 - Aging Research) to the University of Alabama at Birmingham (UAB) to investigate the role of ceramide signaling in regulating healthspan and lifespan in mouse models. The study aims to determine how growth hormone deficiency and altered lipid profiles, particularly ceramides, impact aging and neurodegenerative diseases like tauopathy. The research approach integrates cellular, tissue, and whole-animal studies to...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $378,750 in funding to Saint Louis University to conduct research on the role of cytosolic DNA-induced sterile inflammation in driving cellular and organismal progeria/aging hallmarks. The key objectives are to: 1) define the non-canonical mode of STING stimulation upon progerin-induced accumulation of cytosolic DNA, 2) examine how STING, STAT1, and downstream interferon-stimulated genes like...

This federal Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to elucidate the role of hyaluronan matrices on the establishment and maintenance of ovarian reserve and reproductive longevity. The $232,308 award to the Magee-Womens Research Institute and Foundation in Pittsburgh, PA, will be used to test the hypothesis that the stromal...

This $3.6 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at the Icahn School of Medicine at Mount Sinai directed at understanding the role of glial cell interactions surrounding amyloid plaques in the progression of Alzheimer's disease. As part of the Aging Research program (CFDA 93.866), the three-year award will support investigation of how deletion of the Plexin-B1 gene impacts glial network formation and the...

This $500,000 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) will support Sxrna Technologies, Inc. in developing an organoid toolkit for Alzheimer's disease (AD) and Alzheimer's-disease-related dementias (ADRD). The company aims to create a platform for identifying senescent cells in living tissue, which can provide insights into the aging process and enable high-throughput drug screening in complex 3D tissue models. Specifically, the grant will fund...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $1,583,383 to the University of Connecticut Health Center (UCHC) for a research project titled "Regulation of FLT 1 Splicing by Fibronectin and Integrin Signaling During Aging." The research aims to elucidate the molecular mechanisms by which age-related vascular changes,...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is focused on investigating a molecular pathway that links protein N-glycosylation in the endoplasmic reticulum (ER) to the WNT cell-cell signaling pathway. The research aims to delineate the components and mechanisms of this regulated N-glycosylation pathway, understand its role in osteoblast differentiation...