Project Grant R01MH144829
- The National Institute of Mental Health awarded $451,000 to The Regents of the University of California, San Francisco on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) for a Project Grant (R21MH144687) running through July 31, 2028. The award funds research to develop synthetic organizer cells that control multi-axis patterning in three-dimensional brain organoids. Current organoid generation methods lack reproducibility in cell-type patterning and spatial...
- The National Institute of Mental Health awarded Emory University $780,866 on July 2, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research on human induced pluripotent stem cell (hiPSC) and progenitor heterogeneity as predictors of variability in three-dimensional human neural differentiation. The award funds the Brain Organoid Hub at Emory University to investigate why region-specific brain organoids derived from hiPSCs exhibit high variability in...
- The National Institute of Mental Health awarded The Johns Hopkins University $538,657 on July 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop Neural Navigator, a standardized platform for quantifying circuit pathophysiology in patient-derived cerebral organoids using multi-electrode array recordings and machine learning-based modeling to decode psychiatric disorder signatures in schizophrenia and bipolar disorder. The project aims to establish reproducible...
- The National Institute of Mental Health awarded the University of Wisconsin - Madison $150,900 under the Mental Health Research Grants program (CFDA 93.242) on September 17, 2025, to investigate the mechanisms underlying the development, evolution, and function of human-specific cortical dopaminergic interneurons. The funded research addresses fundamental gaps in understanding a population of inhibitory interneurons in the human cerebral cortex that produce and release dopamine—a capability...
- The National Institute of Mental Health awarded Neurolux Inc. $1.248 million on September 24, 2025, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate the Compliant Reversible Actuator and Detector Leveraging Electrophysiology for Organoids (ORGANOID-CRADLE). Neurolux will design and validate a multi-functional interface to measure and modulate neural organoid culture activity. The first-generation ORGANOID-CRADLE will integrate a multi-electrode array and...
- The National Institute of Mental Health awarded the Regents of the University of Michigan $429,000 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of gene dosage in synaptic development using human cerebral organoids. The recipient will develop induced pluripotent stem cell-derived cerebral organoids engineered with deletion or duplication of the genomic region surrounding retinoic acid induced 1 (RAI1) to examine how RAI1 dosage...
- The National Institute of General Medical Sciences awarded the University of Wisconsin - Madison $413,001 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational systems for analyzing single-cell and spatial transcriptomics experiments. The recipient will create computational methods to improve downstream analysis of gene-expression data from single-cell and spatial transcriptomics experiments, which measure genome-wide expression in...
- The National Institute of Mental Health awarded New York University $435,974 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop computational models that quantify individual differences in learning and decision-making and predict psychiatric symptoms. The award funds development of a novel computational framework combining recurrent neural networks and dynamical systems theory to model reward learning processes at the individual level rather than group...
- The National Institute of Mental Health awarded $615,444 to the Regents of the University of Minnesota on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop precise functional characterization of the developing infant brain using a clinical 7T MRI scanner. The award funds research to establish reliable quantitative neuroimaging methods for infants during their first year of life, addressing a gap in current knowledge about early brain functional organization...
- The National Institute of Mental Health awarded the Allen Institute $1,880,723 on March 13, 2026, under the Mental Health Research Grants program (CFDA 93.242) to resolve cellular and anatomical complexity of the brainstem using single-cell genomics. The award funds creation of a refined atlas of brainstem cell types through single-cell transcriptomic profiling, spatial transcriptomic profiling, and mapping of projection patterns to transcriptomic cell types. The brainstem contains highly...
The National Institute of Mental Health awarded the University of Wisconsin - Madison $388,750 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop machine learning methods and tools for comparative single-nucleus multiomics analysis between human pluripotent stem cell organoids and developing brains. The award funds development of a machine learning method, referred to as Brain Organoid Manifold Alignment for multiomics data (an extension of the existing BOMA tool), to enable interpretation of developmental gene regulatory mechanisms at the cellular level across in-vivo and in-vitro systems. The project will address the current gap in computational tools for comparing organoids and brain data by extending beyond single-cell RNA sequencing to simultaneously profile gene expression and chromatin accessibility in the same cell. The work leverages NIH-funded datasets from the Brain Initiative consortium and anticipates generation of additional single-nucleus multiomics data from organoids to support comparative analysis of cell-type-specific gene regulatory mechanisms between organoids and brains. Performance occurs in Madison, Wisconsin. The project runs through April 30, 2031. The award is a project grant, the standard assistance type for NIH research funding, supporting a specified project period not to exceed five years with potential for renewal as a new competing request.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $388.8k | 8/4/26 |