Project Grant R01MH144302
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $717,688 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate molecular and epigenetic mechanisms by which postpartum stress interacts with parity to influence vulnerability to perinatal and postpartum mood and anxiety disorders. The recipient will use a parity-by-postpartum-stress mouse model to examine how stress dysregulates dopamine responsiveness via projections...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $839,815 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a clinical and translational research project investigating neuroimmune mechanisms of depression and anhedonia. The project tests the hypothesis that heightened peripheral immune function and increased blood-brain barrier permeability contribute to major depressive disorder and anhedonia severity. Work is...
- The National Institute of Mental Health awarded the Research Foundation For Mental Hygiene, Inc. $467,368 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct an exploratory study investigating the relationship between maternal serotonin levels during early pregnancy and offspring neurodevelopment. The recipient, operating through its New York State Psychiatric Institute division in New York, will analyze existing data from an ongoing prospective cohort...
- The National Institute of Mental Health awarded New York University $771,272 on March 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neuroplasticity of the human maternal brain during pregnancy and its relationship to perinatal mood and anxiety disorders (PMADs). The research examines trajectories of brain structural and functional changes across pregnancy, the role of brain iron in maternal neuroplasticity and PMAD symptoms, and associations between...
- The National Institute of Mental Health awarded $230,388 to the University of California, Los Angeles on December 1, 2025, under the Mental Health Research Grants program (CFDA 93.242) to support a postdoctoral research project dissecting oxytocin neural circuits involved in prosocial behavior. The research examines neural mechanisms regulating allogrooming—grooming behavior directed toward another individual—in mice by investigating the oxytocin receptor system within the brain's social...
- The National Institute of Mental Health awarded New York University $855,442 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize neural signatures of anxiety risk in infancy through longitudinal investigation of the mismatch negativity response as a potential biomarker. The project, titled "Characterizing Neural Signatures of Anxiety Risk in Infancy," recruits 250 mother-infant dyads at high risk for anxiety (with half of mothers carrying...
- The National Institute of Mental Health awarded the University of Florida $535,491 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the mechanisms governing dendritic release of oxytocin in the central nervous system. The project, titled "Mechanisms Governing Dendritic Release of Oxytocin in the CNS," addresses how oxytocin synthesized in hypothalamic neurons is released not only from axon terminals but also from dendrites, creating...
- The National Institute of Environmental Health Sciences awarded Icahn School of Medicine at Mount Sinai $1.42 million on September 17, 2025, under the Environmental Health program (CFDA 93.113) to investigate the urban-social exposome on maternal depression. The research investigates how stress, built environment factors, and urban exposures—including particulate matter (PM2.5)—act as causal factors in maternal depression through effects on key biological pathways such as inflammation, hormone...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $827,879 on March 25, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate ghrelin receptor and striosomal interactions in stress-induced decision-making. The award supports basic neuroscience research examining how chronic stress exposure alters decision-making through interactions between neural circuits and endocrine mechanisms. The research uses mouse models to explore how...
- The National Institute of Mental Health awarded Yale University $1,678,658 under the Mental Health Research Grants program (CFDA 93.242) on May 1, 2026, to conduct the first known in vivo human positron emission tomography imaging study measuring how menopause affects synaptic density in the corticolimbic regions of the brain, whether major depressive disorder exacerbates menopause-related alterations in synaptic density, and how these synaptic changes correlate to objective and subjective...
The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $861,666 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a prospective pregnancy cohort study examining the combined role of endogenous and exogenous oxytocin in postpartum depression and anxiety risk. The study will recruit participants during the second or third trimester of pregnancy and follow them through three months postpartum to measure depression and anxiety symptoms. The research addresses a gap in existing knowledge by simultaneously measuring cerebrospinal fluid (collected during standard neuraxial anesthesia procedures), blood oxytocin levels, and quantitative pitocin dosing to disentangle how endogenous oxytocin levels during pregnancy and synthetic oxytocin (pitocin) exposure during labor and delivery jointly influence postpartum mood and anxiety disorders. Previous studies have lacked both quantitative pitocin dosing data and concurrent measurements of endogenous and exogenous oxytocin levels. The study hypothesizes that lower endogenous oxytocin in pregnancy is a promising biomarker for identifying women at risk and informing targeted prevention and treatment strategies. Performance of work occurs in New York, New York. The project period runs through April 30, 2031. This is a Project Grant, the standard NIH research grant mechanism with a support period not to exceed five years.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $861.7k | 7/21/26 |