Project Grant R01MH144082
- The National Institute of Mental Health awarded $158,696 to the University of Puerto Rico Medical Sciences Campus on December 2, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how GABAergic neurons in the ventral pallidum and their projections to the lateral hypothalamus encode and modulate opposing behavioral responses during motivational conflict. The research uses fiber photometry and optogenetics to characterize how ventral pallidum GABAergic neuronal...
- This $409,750 project grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to characterize the role of ventral pallidal astrocytes in approach/avoidance conflict behaviors in mice. The 2-year project, running from April 1, 2025 to March 31, 2027, will utilize fiber photometry and chemogenetic manipulations to investigate how astrocytes in the ventral pallidum regulate synapses and influence approach/avoidance behaviors...
- The National Institute of Mental Health awarded the University of Texas Health Science Center at Houston $114,792 on December 18, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of prefrontal cortex circuits in risky decision-making. The project runs through December 22, 2027, with performance at Houston, Texas. The research identifies neural mechanisms controlling the balance between reward seeking and threat avoidance by examining...
- The National Institute of Mental Health awarded The Washington University $735,920 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neural mechanisms of threat learning and avoidance behaviors. The research elucidates the temporal dynamics and causal roles of neurons in the supramammillary nucleus during threat learning, avoidance, and extinction using fiber photometry, optogenetics, and behavioral assays. The project determines whether these...
- The National Institute of Mental Health awarded the University of California, Los Angeles $180,670 on October 25, 2025, under the Mental Health Research Grants program (CFDA 93.242) to conduct research on the neuronal correlates of avoidance and pursuit during human ambulatory navigation. The project investigates how the medial temporal lobe, including the hippocampus and amygdala, supports simultaneous reward-seeking and risk-aversion during naturalistic navigation in freely-moving humans. UCLA...
- The National Institute of Mental Health awarded the University of California, San Diego $399,950 under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2026, to investigate reactive oxygen species–mitochondrial–calcium axes in neuronal function. The award funds basic research into the molecular mechanisms underlying neuronal physiology, with potential implications for understanding mental health disorders. The project extends through April 30, 2031, and is performed in La...
- The National Institute of Mental Health awarded the University of Wyoming $397,375 on June 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of medial prefrontal cortex long-range recurrent neural networks in behavioral initiation and inhibition. The project, R21MH141703, will employ four translational behavioral paradigms (head-fixed persistent licking and shock-escape tasks; freely moving Fed3-based reversal learning and stop-signal tasks) combined...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
- The National Institute of Mental Health awarded the University of Pittsburgh $705,236 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate spatially-organized prefrontal circuits regulating fear expression and discrimination. The research examines how the rostral and caudal prelimbic cortex of the mouse brain differentially regulate fear responses to threats versus non-threats. The work addresses the pathogenesis of anxiety and trauma-related...
- The National Institute of Mental Health awarded $1.579 million to the Research Foundation For Mental Hygiene, Inc., operating as the New York State Psychiatric Institute, on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to fund basic neuroscience research into the circuit mechanisms by which early-life adversity produces sustained reward deficits. The research examines how childhood trauma—including abuse, neglect, and chronic stress—alters neural circuits governing...
The National Institute of Mental Health awarded the University of Puerto Rico Medical Sciences Campus $706,471 on August 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize the neuronal substrates governing approach and avoidance conflict behavior in mice. The recipient will conduct three research aims using fiber photometry, virally-mediated cellular signal ablation, and optogenetics in mice trained in platform-mediated avoidance tasks. Aim 1 characterizes how nucleus accumbens neurons and astrocytes encode approach and avoidance conflict learning and expression via calcium fiber photometry. Aim 2 ablates signaling of nucleus accumbens neurons and astrocytes to probe their role in approach and avoidance conflict learning. Aim 3 uses optogenetic silencing of nucleus accumbens neurons and astrocytes to probe their role in conflict expression. The research addresses a knowledge gap in understanding how opposing motivational circuits interact during conflict, with implications for anxiety, depression, and addiction. The award is a Project Grant, assistance type standard for NIMH research support. The period of performance runs through April 30, 2031. Work is performed in Puerto Rico. The University of Puerto Rico serves as the parent organization; the Medical Sciences Campus is the immediate recipient.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $706.5k | 8/6/26 |