Project Grant R01MH143963
- The National Institute of Mental Health awarded the University of Rochester $437,496 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate blood-brain barrier and glymphatic clearance disruptions as biomarkers for schizophrenia spectrum disorders in mid- to late-life first episode psychosis. The research examines interactions among three barrier systems regulating trafficking between blood and brain: the blood-brain barrier, blood-cerebrospinal fluid...
- The National Institute of Mental Health awarded The Feinstein Institutes for Medical Research $795,165 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate microRNAs in neural-derived extracellular vesicles as diagnostic and treatment response biomarkers in first-episode schizophrenia. The research addresses the clinical gap in schizophrenia diagnosis and treatment assessment, which currently relies on psychiatric interviews without reliable biomarkers to...
- The National Institute of Mental Health awarded The Johns Hopkins University $807,893 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct advanced magnetic resonance imaging research on neurovascular abnormalities in individuals with schizophrenia across the life span. The recipient will perform quantitative MR imaging at 7 Tesla field strength to test the hypothesis that cerebral microvasculature and cerebrospinal fluid circulation and clearance...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $462,000 on August 14, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop a novel spatial transcriptomics platform and investigate RNA-binding protein function in human neurons as it relates to schizophrenia risk. The award funds two primary aims. The first develops a spatial RNA-protein interactome MERFISH (SPRIM) platform to visualize endogenous RNA-protein interactions at...
- The National Institute of Mental Health awarded The Research Foundation For The State University Of New York, doing business as SUNY Downstate Health Sciences University, $814,434 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate molecular networks of memory maintenance and dysfunction in neural circuits. The research examines how networks of molecules persistently modify neuronal ensembles to store long-term memory, with specific focus on the...
- The National Institute of Mental Health awarded The Research Foundation For The State University Of New York $802,543 on June 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to dissect the role of astrocytes in mediating adverse outcomes of maternal immune activation. The project grant funds research examining how prenatal infections triggering maternal immune activation contribute to neurodevelopmental disorders including schizophrenia, autism spectrum disorder, and...
- The National Institute of Mental Health awarded $1,463,483 to the Research Foundation For Mental Hygiene, Inc., operating through its Nathan S Kline Institute, on September 19, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate sensory contributions to third visual pathway dysfunction in schizophrenia, with work performed in Orangeburg, New York through July 31, 2030. The project examines neural mechanisms underlying social cognitive deficits in schizophrenia by...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Research Foundation For The State University Of New York $244,500 on August 15, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and mechanistically characterize sulfonium-based lipid nanoparticles for mRNA and CRISPR/Cas9 delivery to the brain. The award funds research to elucidate how sulfonium-based lipid nanoparticles mediate...
- The National Institute of Mental Health awarded New York University School of Medicine $100,228 on November 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project examining cerebellar contributions to schizophrenia spectrum disorders. The research uses multimodal neuroimaging techniques—resting-state functional MRI, diffusion MRI, and multi-echo gradient imaging—to investigate how cerebellar abnormalities contribute to cognitive deficits in young adults...
- The National Institute of Mental Health awarded the University of Southern California $249,000 on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support basic research on the dysbindin-1–SRC–GluN2A pathway as a mechanism to restore glutamate receptor function in schizophrenia. The research employs a cell-circuit-behavior approach to assess how dysbindin-1 and SRC regulate N-methyl-D-aspartate receptor (NMDAR) signaling and working memory. The study will measure...
The National Institute of Mental Health awarded The Research Foundation For The State University Of New York $807,460 on July 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate blood-brain barrier leakiness and neuroinflammation in schizophrenia. The recipient will conduct single-cell RNA sequencing of midbrain tissue to identify molecular communication pathways through which resident and invading immune cells disrupt brain homeostasis and damage dopamine neurons. The work will characterize transcriptional and morphological changes in endothelial cells during brain inflammation, map key molecular and cellular changes underlying a leaky blood-brain barrier in proximity to dopamine neurons in the schizophrenia midbrain, and identify serum biomarkers that distinguish inflammatory states and correlate with blood-brain barrier status by linking central and peripheral measures using machine learning. The research will examine multiple inflammatory pathways, assess whether transcriptional profiles, numbers, or sizes of dopamine neurons differ with inflammation and schizophrenia diagnosis, and support development of novel anti-inflammatory and blood-brain barrier-strengthening treatments. The Research Foundation For The State University Of New York, operating as Upstate Medical Center, is the sponsored programs administrator and fiscal agent for the State University of New York system. Work will be performed in Syracuse, New York, with a period of performance from July 24, 2026, through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $807.5k | 7/28/26 |