Project Grant R21MH137547
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Rochester a $423,500 Project Grant under the Mental Health Research Grants program (CFDA 93.242) on May 5, 2025, with a completion date of May 4, 2027. This award supports research investigating visual perception and predictive processing dysfunction in schizophrenia and related psychiatric disorders. The research employs high-density electroencephalography (EEG) and innovative visual...
- Federal Project Grant Award Summary New York University School of Medicine received a $815,251 project grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective June 1, 2025, through March 31, 2030. The award funds a comprehensive evaluation of Medicaid Delivery System Reform Incentive Payment (DSRIP) programs and their impacts on healthcare utilization, care coordination, and health outcomes among Medicaid enrollees with...
- Federal Grant Award Summary The University of Rochester received a $174,381 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective September 1, 2025, through August 31, 2029. This award supports the development and testing of evidence-based interventions for deaf adults to reduce suicide risk and improve mental health treatment engagement. The research project delivers two primary products: (1) the development of...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Pittsburgh a Project Grant of $1,004,971 under the Mental Health Research Grants program (CFDA 93.242) on April 8, 2026, with a completion date of February 28, 2029. The award supports the development of an integrated research platform designed to measure and analyze brain activity, cognitive states, behavior, and physiology in real-world settings. The project leverages a unique clinical...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a $804,690 Project Grant under the Mental Health Research Grants program (CFDA 93.242), effective June 12, 2025 through April 30, 2030. This research project investigates the relationship between N-acetyl-aspartyl-glutamate (NAAG), a peptide neurotransmitter, and memory deficits in schizophrenia patients in mid- to late-life. The primary deliverable involves measuring NAAG levels using...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Feinstein Institutes for Medical Research a Project Grant of $519,558 under the Mental Health Research Grants program (CFDA 93.242), effective June 15, 2025 through April 30, 2030. The research project focuses on identifying and validating cerebellar-cortical circuitry biomarkers as predictive indicators of antipsychotic treatment response in first-episode psychosis patients. The primary deliverables...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded $843,322 to the Research Foundation For Mental Hygiene, Inc. (New York State Psychiatric Institute) on March 5, 2026, under the Mental Health Research Grants program (CFDA 93.242). This Project Grant supports longitudinal positron emission tomography (PET) imaging research investigating antipsychotic medication binding to the dopamine-3 receptor (D3R) in schizophrenia patients through November 30, 2030. The...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded $394,200 to the Research Foundation For Mental Hygiene, Inc. (through its New York State Psychiatric Institute division) under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2025, for a five-year project period extending through July 31, 2030. This Project Grant funds a clinical research study examining the role of the anterior hippocampus in major depressive disorder (MDD) pathogenesis....
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded $818,253 to The Regents of the University of California, San Francisco under the Mental Health Research Grants program (CFDA 93.242) beginning July 1, 2025, and extending through April 30, 2030. This Project Grant supports a five-year research investigation examining neuromodulatory system abnormalities in late-life depression (LLD), with specific focus on the associations between structural and functional brain...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the Regents of the University of Michigan a $2.9 million Project Grant (CFDA 93.242: Mental Health Research Grants) effective September 22, 2025, through September 21, 2029, to conduct basic neuroscience research on midbrain signals for differential reinforcement learning. The research employs two-photon calcium imaging to investigate learning-related neural activity in the inferior colliculus shell region of...
The University of Rochester received a $437,496 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) for the period April 1, 2026 through March 31, 2028. This research project investigates brain barrier and glymphatic clearance disruptions as biomarkers for schizophrenia spectrum disorders (SSD), with particular focus on mid- to late-life first episode psychosis (FEP). The deliverables include research findings examining the interrelated dysfunction of three critical brain barrier systems: the blood-brain barrier (BBB), blood-cerebrospinal fluid barrier (BCSFB), and glymphatic system (GS). The project applies advanced neuroimaging techniques, including dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and blood-based biomarker methodologies to assess barrier function and identify novel diagnostic and prognostic markers for SSD. This research addresses a significant gap in the literature, as fewer than 1% of existing pathophysiological studies in SSD have focused on mid- to late-life FEP despite heterogeneity in clinical presentation and disease mechanisms. The expected research products include peer-reviewed publications, mechanistic insights into brain barrier dysfunction in psychotic disorders, and validated biomarkers that could advance understanding and treatment of mental illness consistent with NIMH's mission to transform the understanding and treatment of mental illnesses through basic and clinical research.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $437.5k | 4/1/26 |