Project Grant R01MH143819
- The National Institute of Mental Health awarded Cincinnati Children's Hospital Medical Center $820,196 on March 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct observational and mechanistic research on circadian misalignment in adolescents with attention-deficit/hyperactivity disorder (ADHD). The project investigates how the timing mismatch between adolescents' internal circadian phase and early school start times affects attention and functional outcomes in...
- The National Institute of Mental Health awarded the University of Southern California $110,228 on November 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate longitudinal effects of ADHD medication usage on neurodevelopment in adolescents. The project analyzes three waves of data (ages 9–10, 11–12, and 13–14 years) from the Adolescent Brain and Cognitive Development (ABCD) study cohort of 11,800 participants to identify cortical, subcortical, and white matter...
- The National Institute of Mental Health awarded the University of Illinois at Chicago $110,228 on January 1, 2027, under the Mental Health Research Grants program (CFDA 93.242) to investigate menstrual cycle effects on mood episodes and suicidality in adolescent female psychiatric patients. The project will examine whether cyclical fluctuations in ovarian hormones function as a biological trigger for suicidality in adolescents with brain sensitivity to hormonal changes. The study builds on a...
- The National Institute of Mental Health awarded the University of North Carolina at Chapel Hill $163,866 on November 1, 2025, under the Mental Health Research Grants program (CFDA 93.242) to examine estradiol variability's effects on dopaminergic reward circuitry in perimenopausal anhedonia. The recipient will conduct research examining the neurobiological mechanisms linking estradiol flux and anhedonia during perimenopause using simultaneous PET-MR imaging. The work comprises four objectives:...
- The National Institute of Mental Health awarded Florida International University $809,160 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and test novel approaches to supporting elementary school students with ADHD within multi-tiered systems of support (MTSS). The project, titled "Novel Approaches to Supporting Students with ADHD in Multi-Tiered Systems of Support," addresses behavioral difficulties in the classroom that inhibit...
- The National Institute of Mental Health awarded Seattle Children's Research Institute $895,798 on August 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a randomized hybrid implementation-effectiveness trial evaluating motivational interviewing enhanced cognitive behavior therapy for adults with ADHD. The trial will test combined CBT+MI against CBT alone, enrolling 216 adults with ADHD across 72 independent telepsychology providers licensed as psychologists with...
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $474,500 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the relationship between puberty, interoceptive neural networks, and anxiety symptoms in adolescents. The research employs functional magnetic resonance imaging to characterize how pubertal changes to cortical body representation in primary somatosensory and insular cortices relate to...
- The National Institute of Mental Health awarded the Regents of the University of Minnesota $118,589 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how neuroendocrine transitions during adolescence shape depression risk and salience network development. The research characterizes menarche and menstrual cycle stabilization as components of a neuroendocrine transition underlying adolescent vulnerability to depression. Aim 1 uses data from the...
- The National Institute of Mental Health awarded Yale University $1,678,658 under the Mental Health Research Grants program (CFDA 93.242) on May 1, 2026, to conduct the first known in vivo human positron emission tomography imaging study measuring how menopause affects synaptic density in the corticolimbic regions of the brain, whether major depressive disorder exacerbates menopause-related alterations in synaptic density, and how these synaptic changes correlate to objective and subjective...
- The National Institute of Mental Health awarded Cincinnati Children's Hospital Medical Center $802,494 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a longitudinal study of cognitive disengagement syndrome as a transdiagnostic predictor of psychopathology across adolescence. The funded research extends an ongoing longitudinal study tracking 341 community-recruited adolescents (ages 10–12 years at baseline, enriched for cognitive disengagement syndrome...
The National Institute of Mental Health awarded The University of Kentucky Research Foundation $2,695,895 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a longitudinal study examining the relationship between circulating estrogen levels and ADHD symptoms, cognitive performance, and affective outcomes in adolescent girls across the menstrual cycle. The study will recruit 100 adolescents under age 18 at later pubertal stages with regular menstrual cycles who exhibit inattention, overactivity, or impulsivity problems. Participants will undergo comprehensive ADHD assessment, psychopathological evaluation, and cognitive and affective testing at baseline, then provide repeated saliva hormone samples during laboratory visits to enable within-person measurement of estrogen fluctuations across the menstrual cycle. The research will employ intensive longitudinal measurement to examine whether within-person declines in estrogen around ovulation and at cycle end predict clinically significant increases in ADHD symptoms, worsening cognitive performance, and increased negative affect—a question the source indicates remains virtually unstudied in adolescents despite pilot data suggesting the relationship in young women. The award supports work performed in Lexington, Kentucky, with a period of performance from September 1, 2026, through August 31, 2030. The assistance type is a Project Grant, a standard research grant mechanism under NIMH's portfolio supporting basic and clinical research to advance understanding and treatment of mental illnesses.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.7m | 8/26/26 |