Project Grant K99MH146385
- The National Institute of Mental Health awarded the University of Illinois at Chicago $110,228 on January 1, 2027, under the Mental Health Research Grants program (CFDA 93.242) to investigate menstrual cycle effects on mood episodes and suicidality in adolescent female psychiatric patients. The project will examine whether cyclical fluctuations in ovarian hormones function as a biological trigger for suicidality in adolescents with brain sensitivity to hormonal changes. The study builds on a...
- The National Institute of Mental Health awarded the Regents of the University of Minnesota $403,282 on August 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop AI-based screenomic analysis methods for studying the relationship between adolescent digital experiences and psychopathological symptoms. The research transforms over 38 million smartphone screenshots from 154 adolescents into structured records of digital experiences. The project develops computational...
- The National Institute of Mental Health awarded the Regents of the University of Minnesota $167,473 on January 2, 2026, for a project grant under the Mental Health Research Grants program (CFDA 93.242) to measure neuroplastic effects of oscillation-locked transcranial magnetic stimulation. The research addresses treatment-resistant major depressive disorder, which affects more than 30 percent of individuals with MDD who show no response to two or more antidepressant interventions. The project...
- The National Institute of Mental Health awarded the Regents of the University of Minnesota $410,800 on August 17, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and test the Choose Your Own Adventure (CYOA) application, a personalized intervention designed to help adolescents with depression regulate problematic social media use. The research builds on qualitative studies identifying the "runaway train" effect—a pattern in which algorithmic content...
- The National Institute of Mental Health awarded the University of Oregon $100,138 on February 1, 2027, to conduct longitudinal research characterizing the links between affective development and the emergence of depression symptoms in adolescent girls under the Mental Health Research Grants program (CFDA 93.242). The project analyzes six waves of data from the Longitudinal Transitions in Adolescent Girls Study spanning participants' second decade of life (N=174; age 10–13 at baseline). The...
- The National Institute of Mental Health awarded the Regents of the University of Minnesota $149,177 on February 27, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct research into valuation mechanisms linking phasic and tonic dopamine dynamics and their role in flexible motivational engagement. The award funds a two-aim research project that uses a novel broadband dopamine measurement technique to analyze how dopamine fluctuates across fast phasic and slower tonic...
- The National Institute of Mental Health awarded $615,444 to the Regents of the University of Minnesota on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop precise functional characterization of the developing infant brain using a clinical 7T MRI scanner. The award funds research to establish reliable quantitative neuroimaging methods for infants during their first year of life, addressing a gap in current knowledge about early brain functional organization...
- The National Institute of Mental Health awarded Research Foundation For Mental Hygiene, Inc. (operating through its New York State Psychiatric Institute division) $818,498 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how individual differences in hippocampal gene expression modify susceptibility and resilience to depression following early adversity in adolescents. The research will determine whether innate variation in expression of adversity-,...
- The National Institute of Mental Health awarded The University of Kentucky Research Foundation $2,695,895 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a longitudinal study examining the relationship between circulating estrogen levels and ADHD symptoms, cognitive performance, and affective outcomes in adolescent girls across the menstrual cycle. The study will recruit 100 adolescents under age 18 at later pubertal stages with regular menstrual...
- The National Institute of Mental Health awarded the University of North Carolina at Chapel Hill $163,866 on November 1, 2025, under the Mental Health Research Grants program (CFDA 93.242) to examine estradiol variability's effects on dopaminergic reward circuitry in perimenopausal anhedonia. The recipient will conduct research examining the neurobiological mechanisms linking estradiol flux and anhedonia during perimenopause using simultaneous PET-MR imaging. The work comprises four objectives:...
The National Institute of Mental Health awarded the Regents of the University of Minnesota $118,589 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how neuroendocrine transitions during adolescence shape depression risk and salience network development. The research characterizes menarche and menstrual cycle stabilization as components of a neuroendocrine transition underlying adolescent vulnerability to depression. Aim 1 uses data from the Adolescent Brain Cognitive Development (ABCD) Study (versions 6.0 and 10.0, ages 9–20, N=5,676 females) to quantify how menarche onset influences changes in depressive symptoms and salience network topography, and how age at menarche moderates cumulative risk. Aim 2 investigates menstrual cycle stabilization as a second window of vulnerability using a multi-cohort approach, leveraging a retrospective ultra-high-field 7T dataset (N=45, ages 16–20, approximately 3–11 years post-menarche) and newly collected dense prospective data. Performance runs from September 1, 2026, through August 31, 2028, at Minneapolis, Minnesota. This award is a K99 (Pathway to Independence) grant, made for a two-year period with no renewal.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $118.6k | 9/1/26 |