Project Grant R01MH141757
- The National Institute of Mental Health awarded the University of Illinois $440,908 on July 27, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project investigating the roles of the prefrontal cortex and ventral hippocampus during adolescence in the maturation of social and cognitive behaviors. The research examines how changes in GABAergic inhibitory transmission in these limbic structures contribute to the refinement of higher cognitive functions and social...
- The National Science Foundation Division of Integrative Organismal Systems awarded The University of Chicago $715,655 on October 1, 2025, under the Biological Sciences program (CFDA 47.074) to investigate how multiple brain regions coordinate to support task switching and cognitive flexibility. The research examines a cortex-basal forebrain loop that enables task-specific reorganization of brain activity patterns, contrasting two competing models: an intracortical model in which the cerebral...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $244,428 on August 20, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct research on cholinergic modulation of thalamocortical projections to prefrontal cortex in cognitive flexibility. The research will determine whether acute adult cholinergic modulation in the prefrontal cortex modulates attentional set-shifting performance and whether enhancing...
- The National Institute of Mental Health awarded Johns Hopkins University $608,086 on March 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of the claustrum in flexible decision making. The research tests whether claustrum neurons encode decision variables relevant to cognitive flexibility and whether claustrocortical projections contribute to generating persistent cortical activity in prefrontal cortex areas implicated in behavioral...
- The National Institute of Mental Health awarded the University of Southern California $751,034 on August 6, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a neuroscience research project examining how the brain processes uncertainty in noisy, dynamically changing environments. The project, titled "Unraveling Neural Mechanisms Underlying Learning in a Noisy, Dynamically Changing World," investigates computational and neural mechanisms by which the brain...
- The National Institute of Mental Health awarded New York University $226,404 on September 3, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct experimental research examining how memory replay supports continual learning in the brain. The research tests two hypotheses: that the brain forms representations segregating context- and task-specific information while abstracting shared structure across tasks, and that replay supports continual learning by orthogonalizing...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The University of Iowa a Project Grant totaling $732,635 on September 19, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate mediodorsal (MD) thalamus representations underlying human cognitive flexibility. The research addresses critical gaps in understanding how the brain encodes, updates, and generalizes context representations essential for adaptive cognition and task switching....
- The National Institute of Mental Health awarded New York University $435,974 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop computational models that quantify individual differences in learning and decision-making and predict psychiatric symptoms. The award funds development of a novel computational framework combining recurrent neural networks and dynamical systems theory to model reward learning processes at the individual level rather than group...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $194,400 under Project Grant K08MH143093 on May 18, 2026, to elucidate neural activity patterns underlying cognitive flexibility through electrophysiological recording in non-human primates. The recipient will use high-channel count electrophysiological methods to record activity from brain circuits spanning the hippocampus, prefrontal cortex, and motor output regions while non-human...
- The National Institute of Mental Health awarded New York University $710,563 on March 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how orbitofrontal cortex projections to the ventral striatum regulate dynamic learning rates during error-driven learning in rodent models. The research will use optogenetics and electrophysiology to record from and manipulate orbitofrontal cortex neurons projecting to the ventral striatum in rats performing a novel behavioral...
The National Institute of Mental Health awarded The University of Chicago $656,448 on August 25, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neural mechanisms underlying cognitive flexibility and task switching. The research addresses how the brain balances flexibility and stability in routing sensory and contextual information to guide behavior—a balance whose dysfunction characterizes dementia, autism, and substance abuse. The project tests the hypothesis that stimulus-neuron-behavior mappings remain largely stable while context-dependent modulation of neural activity enables behavioral flexibility. The work encompasses three specific aims: investigating neural mechanisms associated with learning new stimulus-reward associations, characterizing mechanisms enabling switches between dramatically different tasks, and using causal manipulations to assess stability of interactions among visual, frontal, and parietal brain areas. Performance takes place in Chicago, Illinois, with a period of performance extending from the award date through April 30, 2031. The assistance type is a Project Grant, a standard mechanism under which NIH funds peer-reviewed research for up to five years.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $656.4k | 8/27/26 |