Project Grant R01MH141342
- The National Institute of Mental Health awarded Massachusetts Institute of Technology (MIT) $803,849 on June 3, 2026, as a Project Grant under the Mental Health Research Grants program (CFDA 93.242) to conduct brain-wide analysis of input/output relationships in the reward system. MIT will use functional magnetic resonance imaging (fMRI) techniques to study integrated input/output relationships between brain regions involved in reward-related tasks. The research centers on a novel genetically...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
- The National Institute of Mental Health awarded Rosalind Franklin University of Medicine & Science $465,301 on July 25, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how social deprivation during adolescence impairs basomedial amygdala development and compromises social behavior. The research examines the role of the basomedial amygdala in regulating social engagement across developmental stages, with specific focus on how atypical social...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $443,575 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how maternal immune activation alters dopamine circuit function and development. The project examines the structural and functional impact of in utero immune activation on the striosome-dendron bouquet, a striatal circuit that directly controls dopamine neurons in the substantia nigra pars compacta. Aim 1...
- The National Institute of Mental Health awarded Yale University $711,168 under Mental Health Research Grants (CFDA 93.242) on September 1, 2026, to identify circuit mechanisms by which insular cortex immune-responsive neurons alter behavior during peripheral inflammation. The project uses mouse models of type 2 and type 3 inflammation combined with single-cell transcriptomics, electrophysiology, and chemogenetics to determine whether insular cortex immune-responsive neurons are heterogeneous and...
- The National Institute of Mental Health awarded $466,175 to Massachusetts General Hospital on August 11, 2026, under the Mental Health Research Grants program (CFDA 93.242) to map neuroimmune circuitry implicated in major depressive disorder and treatment-resistant depression. The recipient will conduct multimodal neuroimaging and anatomical research to elucidate circuits connecting limbic regions with the nucleus tractus solitarii in the brainstem, a neural pathway through which inflammatory...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $805,382 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study social perception and cognition in a marmoset model of Phelan-McDermid Syndrome. The award funds research into neural impairments in social perception and cognition caused by SHANK3 gene mutations, with investigation of whether gene therapy can correct those impairments. MIT will implant electrocorticography...
- The National Institute of Mental Health awarded Massachusetts Eye and Ear Infirmary $666,010 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study co-transmission of GABA and glutamate in cortical circuits and the role of neuromodulatory inputs in adult cortical plasticity. The recipient will employ anatomical circuit tracing, whole-cell electrophysiology, and in vivo two-photon imaging in mouse cortex to investigate how cholinergic and serotonergic...
- The National Institute of Mental Health awarded Georgia TECH Research Corp $2.596 million on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop multiscale models for analyzing multi-animal social interactions and decision-making. The research project, running through March 31, 2030, will develop methods to break down complex multi-animal behaviors into fundamental units and examine how those units combine to form higher-order social behaviors. Work...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $543,711 on August 20, 2026, under the Mental Health Research Grants program (CFDA 93.242, Assistance Listing R01MH145508) to investigate endocannabinoid-mediated inhibitory synaptic mechanisms of hippocampal plasticity using all-optical physiology. The research employs simultaneous patterned optogenetic stimulation and genetically targeted voltage imaging to track synaptic plasticity with millisecond and...
The National Institute of Mental Health awarded Massachusetts Institute of Technology $735,182 under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2026, to investigate how social interactions promote recovery from viral infections through interleukin-10 (IL-10)–mediated mechanisms. The research uses murine models to explore the neural-immune pathways linking social touch, oxytocin, and IL-10 in recovery from virally induced sickness behaviors. The project will determine whether social interaction engages specific sensory neurons responding to social touch (MRGPRB4+ neurons), investigate whether the oxytocin system mediates recovery effects of social touch, and characterize how IL-10 upregulation influences the brain and periphery during recovery. Preliminary studies demonstrate that socially housed mice recover faster from viral mimics than individually housed mice, with faster recovery associated with elevated IL-10 levels; direct IL-10 delivery into the brain of individually housed mice replicates this accelerated recovery. The work is performed in Massachusetts. The period of performance runs from August 1, 2026 through May 31, 2031. The assistance type is a Project Grant, which supports specified project periods not exceeding five years under NIMH's mission to transform understanding and treatment of mental illnesses through basic and clinical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $735.2k | 8/3/26 |