Project Grant R01MH141218
- The National Institute of Mental Health awarded The Johns Hopkins University $538,657 on July 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop Neural Navigator, a standardized platform for quantifying circuit pathophysiology in patient-derived cerebral organoids using multi-electrode array recordings and machine learning-based modeling to decode psychiatric disorder signatures in schizophrenia and bipolar disorder. The project aims to establish reproducible...
- The National Institute of Mental Health awarded the Regents of the University of Minnesota $719,832 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurometabolic dysfunction and cognitive training mechanisms in mid- to late-life schizophrenia. The recipient will conduct an accelerated longitudinal study quantifying brain chemistry in 81 individuals with schizophrenia and 81 healthy controls (aged 35–79) using 7 Tesla magnetic resonance...
- The National Institute of Mental Health awarded the University of Rochester $437,496 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate blood-brain barrier and glymphatic clearance disruptions as biomarkers for schizophrenia spectrum disorders in mid- to late-life first episode psychosis. The research examines interactions among three barrier systems regulating trafficking between blood and brain: the blood-brain barrier, blood-cerebrospinal fluid...
- The National Institute of Mental Health awarded The Feinstein Institutes for Medical Research $795,165 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate microRNAs in neural-derived extracellular vesicles as diagnostic and treatment response biomarkers in first-episode schizophrenia. The research addresses the clinical gap in schizophrenia diagnosis and treatment assessment, which currently relies on psychiatric interviews without reliable biomarkers to...
- The National Institute of Mental Health awarded New York University School of Medicine $100,228 on November 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project examining cerebellar contributions to schizophrenia spectrum disorders. The research uses multimodal neuroimaging techniques—resting-state functional MRI, diffusion MRI, and multi-echo gradient imaging—to investigate how cerebellar abnormalities contribute to cognitive deficits in young adults...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a Project Grant of $443,931 under the Mental Health Research Grants program (CFDA 93.242) for the period July 1, 2025 through June 30, 2027. This research project aims to develop and validate novel methodologies for accurately tracking structural brain changes using low-field (0.05T) magnetic resonance imaging (MRI) technology coupled with autonomous control systems and...
- The National Institute of Mental Health awarded the University of Pittsburgh $739,727 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop federated statistical harmonization and multivariate modeling frameworks for investigating altered brain aging patterns in individuals with severe mental illness and the modifying effects of metabolic syndrome. The project addresses methodological challenges in large-scale neuroimaging research by leveraging the ENIGMA...
- The National Institute of Mental Health awarded $1,463,483 to the Research Foundation For Mental Hygiene, Inc., operating through its Nathan S Kline Institute, on September 19, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate sensory contributions to third visual pathway dysfunction in schizophrenia, with work performed in Orangeburg, New York through July 31, 2030. The project examines neural mechanisms underlying social cognitive deficits in schizophrenia by...
- The National Institute of Mental Health awarded The Washington University $197,612 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project investigating non-invasive cerebellar stimulation and predictive coding in schizophrenia. The project addresses neurobiological mechanisms underlying delusions in schizophrenia by testing whether cerebellar dysfunction contributes to predictive coding deficits—errors in the brain's ability to update internal...
- The National Institute of Mental Health awarded the University of Texas Health Science Center at Houston $777,176 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and test biomarker-supported prevention intervention for schizophrenia spectrum disorder in at-risk children. The project will recruit children aged 9 to 18 with significant family history of schizophrenia spectrum disorder and other modifiable risk factors but without subclinical or...
The National Institute of Mental Health awarded The Johns Hopkins University $807,893 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct advanced magnetic resonance imaging research on neurovascular abnormalities in individuals with schizophrenia across the life span. The recipient will perform quantitative MR imaging at 7 Tesla field strength to test the hypothesis that cerebral microvasculature and cerebrospinal fluid circulation and clearance deteriorate with aging in schizophrenia, resulting in impaired cognition, functional capacity, brain aging, and treatment response. The study will recruit 90 individuals with schizophrenia or schizoaffective disorder, ranging in age from 18 to over 70 years, and 60 matched controls from an ongoing Schizophrenia Phenotype Study. Each participant will receive comprehensive diagnostic, clinical, and neuropsychological assessment followed by MRI scanning. In Aim 1, the team will use a novel imaging method called IVASO to map arteriolar cerebral blood volume as a key measure of microvasculature. In Aim 2, quantitative MRI will measure cerebrospinal fluid circulation and clearance dynamics. The performance period runs from August 1, 2026, through April 30, 2031, with work conducted in Baltimore, Maryland. This is a Project Grant, the standard assistance type for NIMH research funding with a project period not to exceed five years.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $807.9k | 8/4/26 |