Project Grant R01MH136109

Award Date 7/15/25
Completion Date 4/30/30
Dollars Obligated $734K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Pittsburgh, PA 15222, USA
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This federal Project Grant award of $734,220.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to investigate the impact of early life adversity on positive affect and its neural underpinnings. The University of Pittsburgh will conduct this research, which includes:

  1. Determining if there is a reduction in the behavioral persistence or intensity of positive affect for youth exposed to adversity.
  2. Examining if individual differences in neural reactivity (persistence and intensity) relate to adversity and positive affect.
  3. Interrogating if sex moderates the neural and behavioral dynamics related to positive affect.

The research will leverage ecological momentary assessments, affective film viewing paradigms, and multimodal MRI to explore these questions. The project period runs from July 15, 2025 to April 30, 2030 and seeks to identify critical behavioral and neural mechanisms connected to adversity-related depression risk.

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