This three-year, $3.456 million project grant from the National Institute of Mental Health (NIMH) Mental Health Research Grants program (CFDA 93.242) will fund research into the role of microglia in neurodevelopmental disorders. The grantee, Cold Spring Harbor Laboratory, will merge two-photon imaging of microglia and synapses in the brains of live mice with single-cell genomics and CRISPR screens. This will help define microglia's role in experience-dependent synaptic refinement, a process...
The National Institute of Mental Health (NIMH) awarded a $2,331,491 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Research Foundation For Mental Hygiene, Inc. (RFMH) for the project "Building a Granular Brain-Wide Map of the Serotonin System". The 5-year grant, which began on May 21, 2024, aims to comprehensively map the brain-wide projections of serotonergic neurons and determine the molecular and functional identity of these neurons in...
This is a Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) for the project titled "EARLY LIFE STRESS AND DIFFERENTIAL EFFECTS ON THE MOLECULAR MATURATION OF SPECIFIC SUBTYPES OF BRAIN SEROTONIN NEURONS". The $466,125 grant was awarded on August 25, 2023 to President And Fellows Of Harvard College, acting through the Harvard Medical School Division, to investigate the impact of early life stress and...
The National Institute of Mental Health (NIMH) awarded a $175,344 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Child Mind Institute Inc., a non-profit organization, for a 3-year project to study the relationship between neurotransmitter receptor architecture and functional brain networks across multiple species.
The key objectives are to: 1) develop techniques to align brain data across humans, macaques, marmosets, and rats; 2) analyze how receptor...
This $1,380,070 Project Grant award under the National Institute of Mental Health's (NIMH) Mental Health Research Grants program (CFDA 93.242) will enable Duke University's research team to explore the properties and functions of inhibitory interneurons in the human cerebral cortex. Leveraging live human brain tissue samples and novel genetic tools, the researchers will generate a comprehensive catalog of human cortical interneuron diversity and investigate their roles within neural circuits....
This $1,955,574 Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 Mental Health Research Grants will support research to understand the role of type I interferon-responsive microglia in brain development and circuit maturation. The primary awardee, The Regents of the University of California, San Francisco (UCSF), will conduct this 4.5-year research project to investigate how this microglial subtype engages in the phagocytic elimination of specific...
This $392,500 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research at the University of California, Irvine on the developmental origins of mental illness. Specifically, the project will use large-scale datasets from the Adolescent Brain Cognitive Development (ABCD) and Healthy Brain and Child Development (HBCD) studies to investigate how the structure and connectivity of the hypothalamus are...
This $2,220,017.04 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support a large-scale, single-cell characterization of the molecular and cellular networks governing mood regulation circuitry in major depressive disorder. The study aims to identify transcriptomic changes associated with major depressive disorder in an unprecedented sample of 800 subjects, with a focus on understanding the impact of...
The National Institute of Mental Health (NIMH) awarded a $189,520 Project Grant (CFDA 93.242 Mental Health Research Grants) to Duke University for the "Duke-North Carolina Central University (NCCU)-Interdisciplinary Postdoctoral Training Program in Child Psychiatric and Neurodevelopmental Conditions" (DN-IPT). This 5-year program, effective July 1, 2024, will enroll three new postdoctoral fellows per year to become independent researchers through rigorous training in an...
The National Institute of Mental Health (NIMH) awarded a $234,000 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Colorado-Denver to conduct research on how inhibitory synapses in the brain regulate the formation and function of excitatory synapses throughout development. The project aims to elucidate the cellular and synaptic mechanisms underlying the crosstalk between inhibitory and excitatory synapses, which is critical for maintaining the proper...