The National Institute of Mental Health (NIMH) awarded a $781,119 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Regents of the University of California, San Francisco (UCSF) to support research aimed at "Dissecting the Circuits and Population Dynamics that Represent Unconditioned and Conditioned Stimuli in the Ventral Hippocampus." The 5-year grant, which begins on March 1, 2025 and runs through December 31, 2029, will leverage anatomical targeting, large-scale...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA program 93.242 - Mental Health Research Grants provides $466,757 to the University of Texas at Austin to conduct research on the synaptic plasticity mechanisms that support learning and memory. The primary objectives are to investigate how synaptic active zones and nascent zones are regulated during long-term potentiation and depression, and how this process contributes to the formation of...
The National Institute of Mental Health (NIMH) awarded a $495,907 Project Grant (CFDA 93.242 Mental Health Research Grants) to Florida State University (FSU) to investigate the neurobiological mechanisms underlying the coordination between spatial memory and action. The key objectives are to determine whether the hippocampus-parietal cortex and anterior thalamus-parietal cortex circuits encode information about allocentric (map-like) and egocentric (body-centered) reference frames, and...
This Project Grant award of $242,310 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program supports research to investigate the role of reward mechanisms in episodic memory formation within the hippocampus. The research project, conducted by The Johns Hopkins University, will use in vivo electrophysiology to evaluate how expected and unexpected rewards influence head scanning behavior and the potentiation of hippocampal place fields...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA program 93.242 Mental Health Research Grants, will support research into the neurocircuitry underlying motivated reward-seeking behavior as a coping mechanism for stress. The $606,029 award, effective August 1, 2024 through July 31, 2025, will be administered by the University of Massachusetts Medical School. The key objectives are to investigate how sub-populations of neurons in the medial...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $2,306,736.00 in funding to The Regents of the University of California, San Francisco (UCSF) over the period of Jul 1, 2024 to Jan 31, 2029. The grant supports research to investigate the neural mechanisms underlying intelligent reward-driven learning and decision-making, particularly the role of the hippocampus in model-based computations...
The federal Project Grant award R01MH137156, totaling $625,108, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). This grant supports research to investigate the function of the output layers of the lateral entorhinal cortex (LEC) in associative memory formation. The key objectives of the research are to: 1) identify the roles of serotonin inputs to LEC layer 5/6 neurons in associative learning; 2) determine the function...
This federal Project Grant award of $564,556 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to understand the neural mechanisms underlying rapid instructed task learning (RITL) abilities in humans. The primary objective is to determine how cognitive control networks enable RITL through dynamic representation interactions during task encoding, maintenance, and implementation. The research will leverage a...
This federal Project Grant award in the amount of $1,865,347.00 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant supports research to determine how the molecular heterogeneity of midbrain dopamine neurons contributes to associative learning and motivated behaviors. Specifically, the project will: Identify the neuronal activity signaling patterns of VTA glutamate-dopamine co-releasing neurons,...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports a comprehensive research project to investigate the neural substrates underlying context-dependent decision-making. With total funding of $252,125 over nearly 4 years, the project aims to leverage functional magnetic resonance imaging (fMRI) in behaving mice to identify brain regions involved in maintaining contextual information and...