Project Grant R01MH139864
Award Date
5/8/25
Completion Date
2/28/30
Dollars Obligated
$728K
Federal Agency
National Institute of Mental Health
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Bloomington, IN 47405, USA
Similar Awards
This $185,625 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research on the neural mechanisms underlying socially transmitted aggression in mice. The primary objectives are to: 1) investigate the function of medial amygdala (MeApv) neurons in socially transmitted aggression using chemogenetics, and 2) examine the role of synaptic plasticity at MeApv-VMHvl synapses in modulating socially transmitted...
This $711,897 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to understand the neural mechanisms underlying the relationship between aggression and prosocial behavior. The award to The Leland Stanford Junior University aims to characterize how serotonin release in the nucleus accumbens modulates these opposing social behaviors in mice, particularly in the context of reward frustration. The...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is for a study investigating the causal relationship between pro-inflammatory cytokines and aggressive behavior in human subjects. The $3,350,485 award, with an initial period of performance from Jul 11, 2024 to Mar 31, 2029, aims to demonstrate that an acute pro-inflammatory state induced by an endotoxin challenge will increase aggressive responding, anger...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $237,000 to Northeastern University to investigate the role of the hormone allopregnanolone in producing long-term alterations in the medial prefrontal cortex function of parous (post-pregnancy) animals. The research aims to establish a causal, mechanistic link between the pregnant and post-weaning brain by using pharmacological,...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants supports research to investigate the circuit-specific androgen receptor regulation of hippocampal neuronal excitability. The $178,087 award to Michigan State University (MSU) aims to determine the signaling mechanisms by which androgen receptors reduce ventral hippocampal-nucleus accumbens circuit excitability in both male and female mice. The project...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders CFDA program provides $424,703 to conduct research on circadian timekeeping in Syrian hamster mutants. The project, led by Marquette University, will investigate how changes in molecular clock function translate into phenotype and pathology, leveraging well-characterized circadian clock mutations in the...
The National Institute of Mental Health (NIMH) awarded a Project Grant (CFDA 93.242 - Mental Health Research Grants) totaling $618,863 to the University of Washington to investigate the neural dynamics of fear circuits in ecological rodent models of risk and trauma. The project will leverage the university's established "approach food-avoid predator" paradigm in rats to examine how the amygdala processes and transmits biological threat information, guiding risky goal-directed...
The federal Project Grant award R56MH137986, titled "NEUROCIRCUITRY OF MOTIVATED REWARD-SEEKING AFTER STRESS", was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $606,029 award supports research at the University of Massachusetts Medical School to investigate how the medial habenulo-interpeduncular nucleus (MHB-IPN) brain circuitry mediates the relationship between stress, motivation, and reward-seeking...
This Project Grant award for $667,250.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research focused on the hormonal programming of the mesocorticolimbic circuit during adolescent development. The research aims to understand how gonadal hormones, such as estrogen and testosterone, influence the outgrowth of dopaminergic axons from the nucleus accumbens to the medial prefrontal cortex during this critical...
This federal Project Grant award of $545,759 from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants supports research to determine how enhancing serotonin (5-HT) transmission in the mouse infralimbic medial prefrontal cortex (ILMPFC) during adolescence can suppress activity in ILMPFC somatostatin (SST) neurons. This is expected to augment ILMPFC-mediated top-down regulation of the amygdala and enhance fear extinction in adolescents and adults. The...