Project Grant R01MH139795

Award Date 5/1/25
Completion Date 4/30/30
Dollars Obligated $671K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Birmingham, AL 35294, USA
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The federal Project Grant award R01MH139795, totaling $671,340.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant supports research led by the University of Alabama at Birmingham (UAB) to investigate the role of estradiol regulation in an amygdala microcircuit that processes emotional valence, with a focus on understanding sex differences in conditions like post-traumatic stress disorder (PTSD).

The key objectives of the research project are to: 1) Interrogate estradiol-regulated sites of plasticity in an inhibitory microcircuit involving parvalbumin interneurons and RSPO2 principal neurons in the amygdala using electrophysiology; 2) Establish the causal link between activity in this microcircuit and shifts in valence processing across the reproductive cycle using in vivo calcium imaging and optogenetics; and 3) Determine the role of estradiol signaling in this microcircuit in the development of persistent negative valence following acute stress, which is relevant to PTSD. Successful completion of this 5-year project could elucidate novel cellular mechanisms driving shifts in valence processing across the female reproductive cycle that may confer unique protection against stress.

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